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Anaesthesia and fluorosis.
A 74-year-old man with double vessel coronary artery disease presented with angina on exertion grade II associated with hypertension. He was a reformed smoker and was leading an active life for his age. He came from Jhunjuna province of Rajasthan, India, which is notorious for a high fluoride content in the drinking water. He gave […]
Chronic fluorosis: the disease and its anaesthetic implications..
Abstract Chronic fluorosis is a widespread disease-related to the ingestion of high levels of fluoride through water and food. Prolonged ingestion of fluoride adversely affects the teeth, bones and other organs and alters their anatomy and physiology. Fluoride excess is a risk factor in cardiovascular disease and other major diseases, including hypothyroidism, diabetes and obesity. […]
Methoxyflurane toxicity: historical determination and lessons for modern patient and occupational exposure.
Effect of inhaled anesthetic gases on immune status alterations in health care workers.
Conclusions From the data of this study and the findings of other earlier studies, we can conclude that operating room personnel exposures to WAG are associated with changes in blood levels of IgG and IgM, total lymphocytes, CD4+ and CD8+ subtypes, and accordingly, in CD4:CD8 ratios. It is quite possible these changes would likely be […]
Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice
References 1. Bayer SA, Altman J, Russo RJ, Zhang X: Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 1993; 14:83–144. 2. Rice D, Barone S Jr: Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models. Environ Health Perspect 2000; 108:511–33. 3. […]
Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.
References Lin E.P., Lee J.R., Lee C.S., Deng M., Loepke A.W. Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies. Neurotoxicol Teratol. 2017; 60: 117-128. PubMed Jevtovic-Todorovic V., Olney J.W. PRO: anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg. 2008; 106: 1659-1663. PubMed Loepke A.W. McGowan Jr., F.X. […]
Trace anesthetic effects on perceptual, cognitive, and motor skills.
References 1. Linde HV, Bruce DL: Occupational exposure of anesthetists to halothane. nitrous oxide and radiation. Anesthesiology 30:363-368, 1969. 2. Corbett TH: Retention of anesthetic agents following occupational exposure. Anestl, Analg (Cleve) 52:614-Gli, 1973. 3. Salvini M, Binaschi S, Riva M: Evaluation of the psychophysiological functions in humans exposed to trichloroethylene. Br J Ind Med […]
Psychological studies of human performance as affected by traces of enflurane and nitrous oxide.
Discussion The principal findings of this study were that enflurane affected performance on these tests in a manner qualitatively similar to, though quantitatively different from, halothane. Since the minimum alveolar concentration (MAC), an index of anesthetic potency, is about twice as high for enflurane as for halothane, comparison of the same trace amounts of each […]
The Abortive Lives of Modern Inhalation Anesthetics.
READERS of this periodical were probably intrigued when, in 1971, almost an entire issue was devoted to studies in volunteers of a new anesthetic, isoflurane (Forane), a novel and useful editorial departure. Since then, a series of reports in the Journal has cast further light on some of the more arcane properties of this heavily […]
Fate of fluorinated metabolites of inhalation anesthetics in man.