Abstract
Objective: To study the effects after six months of exposure of mice to increasing concentrations of fluoride in drinking water (tap water, 10, 50, and 100 mg F/L) on their cerebral functions.
Methods: Learning and memory abilities of high-fluoride exposed and control groups of mice were measured by a behavior-toxicological test (Shuttle-box Test), and the cholinesterase (ChE) activity in brain tissue homogenates of the mice was determined.
Results: Learning and memory abilities of the fluoride-exposed groups were significantly lower than those of the control group, and the brain ChE activities of the fluoride-exposed groups were significantly higher.
Conclusions: Elevated fluoride concentration in drinking water can decrease the cerebral functions of mice. Fluoride is a neurotoxicant.
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Changes in learning and memory ability and brain cholinesterase activity in the rats with coal burning fluorosis.
Objective: To observe the influence of coal burning fluorosis on learning and memory ability in rats and reveal its possible mechanisms. Methods: Healthy 48 SD rats were divided into control, low-fluoride and high-fluoride group. All rats in fluoride exposed groups were fed with the eom polluted by drying processes with
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Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats
Nine-six Wistar rats were randomly divided into four groups of 24 rats in each group (female:male = 1:1). Over a period up to 90 days, with one untreated group as controls, the other three groups were administered, respectively, high fluoride (100 mg NaF/L), high arsenic (50 mg As2O3/L), or both
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Decreased learning and memory ability in rats with fluorosis: increased oxidative stress and reduced cholinesterase activity in the brain
The aim of this research was to study the mechanism of the decreased learning and memory of rats with chronic fluorosis. Compared with controls, decreased learning and memory ability, lower levels of total antioxidant capacity (TAOC), and increased content of malondialdehyde (MDA) in brain tissues were observed in both male
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Acetylcholinesterase activity in fluorosis adversely affects mental well-being: an experimental study in rural Rajasthan
Fluoride toxicity is a burgeoning problem worldwide and also in Rajasthan in India. In the state of Rajasthan, almost all districts have high fluoride (up to 18.0 ppm) in their drinking/ground water sources and about 11 million of the population [is] at risk. Several clinical and experimental studies have reported
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Effects of fluoride on learning and memory and cholinesterase activity in rat brains.
Objective: To study the role of fluorosis on learning and memory in rat and its possible mechanisms; to explore the correlation between cholinesterase activity and the level of intelligence. Methods: SD rats divides into 3 group of stochastically according to the sex and the body weight, control group treated with
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are 78 studies reporting reduced IQ (75 studies with children and 3 studies with adults) and several on the impaired learning/memory in animals. And there are studies which link
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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