Abstract
The aim of this research was to study the mechanism of the decreased learning and memory of rats with chronic fluorosis. Compared with controls, decreased learning and memory ability, lower levels of total antioxidant capacity (TAOC), and increased content of malondialdehyde (MDA) in brain tissues were observed in both male and female young adult rats after 6 months with either 5 or 50 mg NaF/L in their drinking water. Interestingly, the activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the brain were reduced more in the rats with the lower NaF concentration than in those with the higher concentration, thereby suggesting a paradoxical dose-response effect of F on these enzymes. The results indicate that the reduced learning capacity and memory ability of rats induced by F may be connected with increased oxidative stress and diminished cholinergic nervous system responses.
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Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats
Nine-six Wistar rats were randomly divided into four groups of 24 rats in each group (female:male = 1:1). Over a period up to 90 days, with one untreated group as controls, the other three groups were administered, respectively, high fluoride (100 mg NaF/L), high arsenic (50 mg As2O3/L), or both
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A correlation between serum vitamin, acetylcholinesterase activity and IQ in children with excessive endemic fluoride exposure in Rajasthan, India
Fluoride is widely distributed in nature and a direct source of adverse health effects in human populations. Fluoride poisoning attributed by long-term exposure to high levels of fluoride [is] called fluorosis. The present study was carried out among 9-14 years old school children of Dausa district, Rajasthan India. The subjects
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Effect of fluorosis on mice learning and memory behaviors and brain SOD activity and MDA content
Objective: Explore the brain mechanism of the effect of fluorosis on learning and memory behavior. Method: A method combining behavioral observation and biochemical testing was used to study the effects of long-term drinking different concentrations of sodium fluoride on mouse learning and memory behavior and changes in content of brain
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Integrated transcriptomic and proteomic analysis indicated that neurotoxicity of rats with chronic fluorosis may be in mechanism involved in the changed cholinergic pathway and oxidative stress.
Highlights Chronic fluorosis decreased learning and memory of rats and induced neurotoxicity. Thirteen corresponding DEGs and DAPs (cor-DEGs-DAPs) were identified. Most of cor-DEGs-DAPs were related to neurodegenerative changes and oxidative stress response The neurotoxicity by high fluoride involved in the changes in cholinergic pathway and oxidative stress. Background To reveal the
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Vitamin A deficiency: An oxidative stress marker in sodium fluoride (NaF) induced oxidative damage in developing rat brain
Fluoride induced oxidative stress through depletion in levels of various anti-oxidants such as glutathione, superoxide dismutase (SOD), fat soluble vitamins (D and E) with increased levels of lipid peroxidation (LPO) and fluoride aggravate the damage in rodents as well as in humans. Vitamins A, a fat soluble vitamin possess antioxidant
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Fluoride & Oxidative Stress
A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. It is also well established that fluoride's toxic effects can be ameliorated by exposure
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Fluoride & IQ: 68 Studies
As of February 2021, a total of 76 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 68 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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