Abstract
Forty-five male patients suffering from chronic fluorine poisoning and fifteen normal men were investigated. The urinary excretion of oestrone, oestradiol-17?, oestriol and 16-epioestriol was studied. The results revealed a high content of oestrogens in urine. This is explained by a metabolic disorder in the liver.
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Biochemical changes in brain and other tissues of young adult female mice from fluoride in their drinking water.
One-month old female Swiss albino mice were given 60 ppm and 120 ppm F– (from NaF) in their drinking water for 30 days to study effects of fluoride on neurotransmitter enzymes (AchE, BchE), anti-oxidant enzymes (SOD, CAT), and lipid peroxidation (MDA) in brain (hippocampus), liver, and gastrocnemius muscle. Activities of AchE and BchE showed a concentration-dependent decrease
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The effects of the inhalation of hydrogen fluoride. II. The response following exposure to low concentration.
The effects of the inhalation of hydrogen-fluoride (7664-39-3) (HF) on several animals was investigated. Five rabbits, three guinea-pigs and two Rhesus-monkeys were exposed to atmospheric HF at a concentration of 0.0152 milligrams per liter for 6 hours a day. This was repeated for 30 days until a total of 309
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Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.
Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary
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Toxicity of fluoride on isolated rat liver mitochondria
Highlights Sodium fluoride exhibited toxic effect on isolated rat liver mitochondria. N-Acetylcysteine protected against the fluoride toxicity on mitochondria. Interfering of fluoride with the mitochondrial functionality can be the result of oxidative stress and subsequent collapse of mitochondrial membrane potential (??m). Fluoride is abundant in the environment and exists mostly in
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Sesamin attenuates histological alterations, oxidative stress and expressions of immune-related genes in liver of zebrafish (Danio rerio) exposed to fluoride.
Highlights Sesamin alleviated histological damage and oxidative stress in liver. Sesamin remarkably inhibited the inflammatory reaction in fluoride-exposed liver. Sesamin reversed activities of immune-related enzymes in fluoride-exposed liver. Sesamin reversed expressions of immune-related mRNAs liver exposed to fluoride. Sesamin could protect liver against fluoride-induced damage. Sesamin is the main lignan in
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