Abstract
One-month old female Swiss albino mice were given 60 ppm and 120 ppm F– (from NaF) in their drinking water for 30 days to study effects of fluoride on neurotransmitter enzymes (AchE, BchE), anti-oxidant enzymes (SOD, CAT), and lipid peroxidation (MDA) in brain (hippocampus), liver, and gastrocnemius muscle. Activities of AchE and BchE showed a concentration-dependent decrease in all the tissues studied, which was highly significant in liver and muscles. Superoxide dismutase (SOD) and catalase (CAT) also showed a significant concentration dependent decrease in all the tissues, which was highly significant for CAT at 120 ppm in liver and muscles. Malondialdehyde (MDA), however, showed a significant concentration dependent increase in gastrocnemius muscle, but in brain and liver it had an initial decrease at 60 ppm F– that changed to a significant increase at 120 ppm. Ascorbic acid exhibited significant concentration-dependent increases in all the tissues examined. Total protein showed a concentration dependent decrease in brain and muscles but an increase in liver. The results of the study indicate that elevated fluoride in drinking water affects not only mammalian neurotransmitter functions but also antioxidant systems.
-
-
Gaseous Anesthetics.
Introduction The history of anesthesia is a relatively recent one; if one begins with the analgesia dentist, Horace Wells, who discovered the used nitrous oxide during a dental extraction in the early 1800s. The first public showing of anesthesia occurred in October 1846, when ether was used to prevent pain during surgery
-
Systematic impacts of fluoride exposure on the metabolomics of rats.
Highlights The risk of chronic endemic fluorosis exists in many countries and regions. Comprehensive metabolomic analysis was used to study the effects of fluoride. Multivariate statistics were used to detect metabolite profile changes. Fluoride exposure caused amino acid, fatty acid, and energy metabolism disorders. Fluoride exposure caused oxidative stress,
-
Effects of fluoride on DNA damage, S-phase cell-cycle arrest and the expression of NF-kappaB in primary cultured rat hippocampal neurons.
The mechanisms underlying the neurotoxicity of fluorosis still remain obscure. To investigate DNA damage, cell-cycle distribution and expression of nuclear factor kappa B (NF-kappaB) induced by fluoride, the primary rat hippocampal neurons were incubated with various concentrations (20mg/l, 40 mg/l, and 80 mg/l) of sodium fluoride for 24 h in
-
Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels.
Previous studies suggest that sodium fluoride (NaF) can impair performance in some memory tasks, such as open-field habituation and two-way active avoidance. In the present study, we evaluated the effect of NaF intake (100 ppm in drinking water for 30 days) and its short-term (15 days) withdrawal on open-field habituation and brain monoamine
-
[Effect of chronic fluorine poisoning on the expression of nNOS protein in Hippocampus of rats].
Objective To investigate the mechanism of chronic fluorine poisoning on hippocampus of rats. Methods The changes of positive nNOS expression in control group given drinking tap water,100 mg/L(low fluorine group),200 mg/L(high fluorine group),were observed by ABC immunohistochemisty. Results The expression of nNOS in the region of CA1, CA3 and dentate gyrus (DG)
Related Studies :
-
-
-
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
-
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
-
Fluoride & IQ: 76 Studies
• As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure
-
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
-
Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
Related FAN Content :
-