Abstract
Objective: Explore the effect of different doses of chronic exposure of fluoride on rat learning and memory behavior. Method: Selected 46 Wistar rats, randomly divided them into a control group, low-fluoride group, and high-fluoride group, had them respectively drink tap water (control group), 100 mg/L (low-fluoride group), and 200 mg/L (high-fluoride group) sodium fluoride solutions, then five months later used a Y-maze test to observe the effect of chronic fluorosis on the learning and memory behavior of the rats. Results: Compared to the number of times required for the control group to learn the Y-maze test (58.83 +/- 25.12), there was a significant increase (P<0.05) in the number of times required by the low-fluoride group (73.95 +/- 9.77) and high-fluoride group (77.37 +/- 8.69) to learn it, and although the number of times required to learn it increased with the fluoride exposure dose, it was not statistically significant (P>0.05). Conclusion: The results indicate that chronic fluorosis has a significant effect on rat learning and memory behavior.
(Translated by Alta Language Services in February 2014, courtesy of Fluoride Action Network)
-
-
Experimental pharmacological researches regarding the influence of sodium fluoride in allopathic and homeopathic doses in central nervous system's performances. A correlation between behavioral response in classic maze test and morphological aspects of cerebral cortex
The influence of fluorine administration on central nervous system’s (CNS) performances in female mice treated during gestation with two distinct doses of sodium fluoride (NaF): 0.25 mg and 0.50 mg. The research extended also to offspring (generation 1 – F1), treated with NaF in allopathic (0.25 and 0.50 mg), homeopathic
-
Chronic aluminum fluoride administration. I. Behavioral observations
This study examined the behavioral effects of chronic ingestion of various monofluoroaluminum complexes (AlF3) in drinking water. Forty young adult male Long-Evans rats were divided into four groups of 10 rats each. The groups received different concentrations of AlF3 in the drinking water from three sample solutions having a total
-
Neuroprotective influence of taurine on fluoride-induced biochemical and behavioral deficits in rats.
Highlights Influence of taurine was studied in rat model of fluoride neurotoxicity. Taurine reversed the fluoride-induced neurobehavioural deficits. Taurine decreased intracellular hydrogen peroxide and lipid peroxidation levels. Taurine reversed the fluoride-induced inhibition of acetylcholinesterase activity. Taurine may be a potential therapeutic agent in fluoride-mediated neurotoxicity. Epidemiological and experimental studies have
-
Protective effect of ascorbic acid and Ginkgo biloba against learning and memory deficits caused by fluoride.
Fluoride is present in the ground water, World Health Organization permitted level of fluoride in the ground water is 0.5 ppm. Tooth pastes, mouth washes, tea and sea fish are the sources of fluoride. Exposure to these multiple sources results in several adverse effects in addition to the fluorosis. The
-
[Effects of selenium on the damage of learning-memory ability of mice induced by fluoride].
Sodium fluoride added with or without selenite in deionized water was administered to male mice for 8 weeks. The influences of fluoride on learning-memory behavior were tested on Y-maze, and the ultrastructure of Gray 1 synaptic interface in the CA3 area hippocampus was qualitatively analyzed by electron microscopy and computer
Related Studies :
-
-
-
Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
-
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
-
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
-
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
-
Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are 78 studies reporting reduced IQ (75 studies with children and 3 studies with adults) and several on the impaired learning/memory in animals. And there are studies which link
Related FAN Content :
-