Abstract
The effects of renal function on urinary fluoride clearance and serum inorganic fluoride concentration were studied. Laboratory determinations including (1) creatinine clearance rate (CCR), (2) serum inorganic fluoride concentration, and (3) urinary fluoride concentration, were made on 122 hospital patients. Subjects were then divided into impaired, questionable and normal creatinine clearance groups. Respectively, the age adjusted mean serum inorganic fluoride concentrations were 0.035, 0.031 and 0.027 ug F/ml for males and 0.033, 0.026 and 0.029 ug F/ml for females. In neither sex were the differences among the three group means statistically significant. The mean urinary 24 hr fluoride excretions in the three groups were 0.30, 0.56 and 0.87 mg respectively for males and 0.24, 0.51 and 0.70 mg for females. For both sexes, the differences among the three group means were statistically significant (p < 0,01). The results suggest that in regions with low fluoride concentrations in the drinking water (0.1 ppm F), impaired creatinine clearance in human subjects is associated with a reduction in urinary clearance of fluoride without simultaneous elevation of serum inorganic fluoride concentration.
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Long-term follow up of ionic plasma fluoride level in patients receiving hemodialysis treatment
The elimination half-life of fluoride is significantly increased in patients with chronic renal failure. This led us to conduct a study of variations of its plasma levels in 35 patients receiving dialysis treatment. In this population, there is a gaussian distribution of the values before and after the hemodialysis session,
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The effect of hemodialysis upon serum levels of fluoride
Serum and dialysate ionic fluoride (F-) were determined in 29 patients under hemodialysis (HD) treatment. Serum creatinine (Cr), blood urea nitrogen (BUN) and phosphorus (P) were also examined before and after HD in 92 patients including the above 29 patients under the same treatment. Results reveal that serum F- levels
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Ionic serum fluoride concentrations and age in a low-fluoride community
Some previous studies indicate extra fluoride retention in human bones caused by severe renal insufficiency. Plasma and serum fluoride concentrations may also be elevated in a fluoridated community. The results from low-fluoride areas are less consistent. The first aim of the present study was thus to test the relation between
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High fluoride concentrations in the serum and bone of patients with chronic renal failure
The aim was to study the effect of ingested fluoride in patients with chronic renal failure (CRF). Serum fluoride concentrations were measured in 104 subjects, who formed three groups: nondialyzed CRF, dialyzed CRF, and a control group. The iliac bone fluoride was measured in 20 subjects. Serum, urine and water
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Serum inorganic fluoride: changes related to previous fluoride intake, renal function and bone resorption
1. Inorganic fluoride concentrations were determined in serum and urine specimens of 24 subjects receiving a standardized low fluoride intake. Serum fluoride was directly correlated with previous intake and appeared to reflect bone fluoride stores. 2. A positive correlation between creatinine and fluoride clearance was found. However, striking reductions in
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