Abstract

The effects of renal function on urinary fluoride clearance and serum inorganic fluoride concentration were studied. Laboratory determinations including (1) creatinine clearance rate (CCR), (2) serum inorganic fluoride concentration, and (3) urinary fluoride concentration, were made on 122 hospital patients. Subjects were then divided into impaired, questionable and normal creatinine clearance groups. Respectively, the age adjusted mean serum inorganic fluoride concentrations were 0.035, 0.031 and 0.027 ug F/ml for males and 0.033, 0.026 and 0.029 ug F/ml for females. In neither sex were the differences among the three group means statistically significant. The mean urinary 24 hr fluoride excretions in the three groups were 0.30, 0.56 and 0.87 mg respectively for males and 0.24, 0.51 and 0.70 mg for females. For both sexes, the differences among the three group means were statistically significant (p < 0,01). The results suggest that in regions with low fluoride concentrations in the drinking water (0.1 ppm F), impaired creatinine clearance in human subjects is associated with a reduction in urinary clearance of fluoride without simultaneous elevation of serum inorganic fluoride concentration.

• Related Studies :

  • Hemodialyzability of ionizable fluoride in hemodialysis session

    The fluoride ion content in serum and in dialysate medium was determined by means of a fluoride ion-selective electrode in 29 patients undergoing hemodialysis treatment. Abnormally high serum fluoride of 65.9 +/- 28.3 microg l(-1) at the beginning and 46.5 +/- 26.7 microg l(-1) at the completion of the hemodialysis

  • Long-term follow up of ionic plasma fluoride level in patients receiving hemodialysis treatment

    The elimination half-life of fluoride is significantly increased in patients with chronic renal failure. This led us to conduct a study of variations of its plasma levels in 35 patients receiving dialysis treatment. In this population, there is a gaussian distribution of the values before and after the hemodialysis session,

  • Serum ionic fluoride levels in haemodialysis and continuous ambulatory peritoneal dialysis patients

    High serum fluoride (F-) in patients with chronic renal failure (CRF) and end-stage renal disease (ESRD) is associated with risk of renal osteodystrophy and other bone changes. This study was done to determine F- in normal healthy controls and patients with ESRD on haemodialysis (HD) or peritoneal dialysis (PD). Seventeen

  • Serum inorganic fluoride: changes related to previous fluoride intake, renal function and bone resorption

    1. Inorganic fluoride concentrations were determined in serum and urine specimens of 24 subjects receiving a standardized low fluoride intake. Serum fluoride was directly correlated with previous intake and appeared to reflect bone fluoride stores. 2. A positive correlation between creatinine and fluoride clearance was found. However, striking reductions in

  • Serum and urine fluoride concentration: relationships to age, sex and renal function in a non-fluoridated population

    Serum and urine fluoride levels were determined in 250 healthy subjects (15-90 years, 122 men and 128 women) residing in Catalonia, Spain, and in 150 patients (20-81 years, 84 men and 66 women) with chronic renal failure undergoing regular dialysis treatment, living in the same geographical area, to determine normal

• Related FAN Content :

  • Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients

    Despite the well known fact that individuals with kidney disease are at much higher risk of fluoride toxicity than the general population, there has yet to be any attempt in the United States, or any other country that practices mass-scale water fluoridation to determine the prevalence of fluoride-related effects (e.g.,

  • Kidney Patients Are at Increased Risk of Fluoride Poisoning

    It is well established that individuals with kidney disease are susceptible to suffering bone damage and other ill effects from low levels of fluoride exposure. Kidney patients are at elevated risk because when kidneys are damaged they are unable to efficiently excrete fluoride from the body. As a result, kidney patients

  • Fluoride & Osteomalacia

    One of fluoride's most well-defined effects on bone tissue is it's ability to increase the osteoid content of bone. Osteoid is unmineralized bone tissue. When bones have too much of it, they become soft and prone to fracture -- a condition known as osteomalacia. As shown below, fluoride has repeatedly been

  • Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence

    A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.

  • Annapolis: Water Fluoridation Linked to Death of Dialysis Patient

    EVENING CAPITAL (Annapolis, Maryland) November 29, 1979 Fluoride Linked to Death by Mary Ann Kryzankowicz Staff Writer Fluoride poisoning has been definitely linked to the death of a 65-year-old kidney dialysis patient who became ill during a blood cleaning process Nov 11. State Medical Examiner Dr. (illegible) Guard has ruled that Lawrence Blake, 65, of Arundel