Abstract
The effects of renal function on urinary fluoride clearance and serum inorganic fluoride concentration were studied. Laboratory determinations including (1) creatinine clearance rate (CCR), (2) serum inorganic fluoride concentration, and (3) urinary fluoride concentration, were made on 122 hospital patients. Subjects were then divided into impaired, questionable and normal creatinine clearance groups. Respectively, the age adjusted mean serum inorganic fluoride concentrations were 0.035, 0.031 and 0.027 ug F/ml for males and 0.033, 0.026 and 0.029 ug F/ml for females. In neither sex were the differences among the three group means statistically significant. The mean urinary 24 hr fluoride excretions in the three groups were 0.30, 0.56 and 0.87 mg respectively for males and 0.24, 0.51 and 0.70 mg for females. For both sexes, the differences among the three group means were statistically significant (p < 0,01). The results suggest that in regions with low fluoride concentrations in the drinking water (0.1 ppm F), impaired creatinine clearance in human subjects is associated with a reduction in urinary clearance of fluoride without simultaneous elevation of serum inorganic fluoride concentration.
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Ionic serum fluoride concentrations and age in a low-fluoride community
Some previous studies indicate extra fluoride retention in human bones caused by severe renal insufficiency. Plasma and serum fluoride concentrations may also be elevated in a fluoridated community. The results from low-fluoride areas are less consistent. The first aim of the present study was thus to test the relation between
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Studies on serum fluoride and bone metabolism in patients with long term hemodialysis
With growing experience of the long-term treatment of patients with end stage renal disease by hemodialysis, the safety of fluoridated water supply for dialysate and the effect on the bone metabolism has been discussed. In this study, concentrations of fluoride (F), calcium (Ga). aluminum (AI) and biochemical indices of bone metabolism,
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Ionic plasma fluoride concentrations related to some diseases in patients from a fluoridated community
Little data is available concerning the relationship between variations in ionic plasma fluoride (IPF) concentrations and some diseases, and that which exists is inconclusive. The effect of renal insufficiency is known best, but the relationship between IPF levels and some oedematous diseases and diabetes has hardly been studied at all
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The relationship between human ionic plasma fluoride and serum creatinine concentrations in cases of renal and cardiac insufficiency in a fluoridated community
Previous studies have shown that renal and cardiac insufficiency cause an elevation of ionic plasma fluoride (IPF) concentration in patients suffering from these diseases. The relationship between serum or plasma fluoride concentration and the degree of renal impairment has been tested only twice; with somewhat contrasting results, although some previous
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Serum inorganic fluoride: changes related to previous fluoride intake, renal function and bone resorption
1. Inorganic fluoride concentrations were determined in serum and urine specimens of 24 subjects receiving a standardized low fluoride intake. Serum fluoride was directly correlated with previous intake and appeared to reflect bone fluoride stores. 2. A positive correlation between creatinine and fluoride clearance was found. However, striking reductions in
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Mayo Clinic: Fluoridation & Bone Disease in Renal Patients
The available evidence suggests that some patients wtih long-term renal failure are being affected by drinking water with as little as 2 ppm fluoride. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers and if fluoride is indeed the cause. It would seem prudent, therefore, to monitor the fluoride intake of patients with renal failure living in high fluoride areas.
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