Abstract
The cardiotoxic effect of various dosage of sodium fluoride was investigated. Three-week-old male Wistar rats were fed on normal fodder and distilled water containing different dosages (0, 25, 50, 100 and 150 mg/litre) of sodium fluoride for 6 months to establish an animal model of chronic fluorosis. Electrocardiogram (ECG) was taken after the experiment for 6 months to observe the effects of fluoride. The morphological changes were observed under transmission electron and light microscopes. There was a shortness of Q-T interval in rats with fluorosis. The morphological changes observed in myocardial tissue under the light microscope were indistinct transverse striation and myolysis or myocardial fibre coagulation. The mitochondria were swollen under transmission electron microscope in rats with fluorosis. It is concluded that fluorosis can cause myocardial cell damage and changes in myocardial structure and ECG in rats.
-
-
Changes of the heart muscle due to chronic fluorosis. Part 2: Experimental studies on the effects of sodium fluoride upon the heart muscle of rabbits
In the electrocardiogram of rabbits given sodium fluoride orally, a pattern of myocardial damage was observed, namely depressed ST, inverted T, prolonged QT interval, multifocal ventricular premature contraction, bundle branch block, and pulmonary P. Histologically, regressive degeneration, cellular infiltration, hyperemia, hemorrhages and thickening of vessel wall were noted in the
-
Electrocardiographic evaluation in patients with endemic fluorosis without clinically evident heart disease
Objective: This study was carried out to analyse the electrocardiogram (ECG) in patients with endemic fluorosis. Methods: Fifty six patients with endemic fluorosis and 44 age, sex and body mass index (BMI) matched healthy controls with normal fluoride intake underwent standart 12-lead ECG, urine fluoride level and serum sodium, potassium,
-
Ca2+ metabolic disorder and abnormal expression of cardiac troponin involved in fluoride-induced cardiomyocyte damage.
Highlights F induced cardiomyocyte damage. F induced Ca2+ metabolic disorder. F inhibited the expression of cardiac troponin. F induced ultrastructure damage in cardiomyocytes. F interfered with production of ATP in cardiomyocytes. Our previous study indicated that excessive fluoride (F) induces ATP5J and ATP5H proactive expression by interfering cardiomyocyte mitochondrial dysfunction in
-
Aortic calcification in chronic fluoride poisoning: biochemical and electronmicroscopic evidence
Fluoride is known to cause ectopic calcification. The biochemical mechanism(s) involved in the initiation of calcification is not understood and the accompanying ultrastructural changes remain to be elucidated. Therefore, certain relevant parameters have been investigated in the aorta of rabbits administered fluoride, 10 mg NaF/kg body wt, every 24 hr
-
Electrocardiographic studies of the inhabitants in high fluoride districts
1) In the Aso-volcano district, a higher incidence of myocardial damage based on electrocardiographic studies was found in inhabitants of high fluoride communities than in "nonfluoride" villages. 2) In subjects with mottled teeth, greater myocardial damage was encountered electrocardiographically than in persons without mottling in the Asovolcano district. 3) The authors conclude
Related Studies :
-
-
-
Fluoride & Arteriosclerosis
Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the
-
Fluoride, Blood Pressure and Hypertension
Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et
-
Fluoride & Myocardial Damage
Structural damage to the heart resulting from fluoride toxicity has been observed in numerous human and animal studies. The general features of this damage include cloudy swelling, vacuolization or vacuolar degeneration, hemorrhages, interstitial edema, fibrous necrosis, dissolution of nuclei, and thickening of the vessel walls in the heart muscle (Basha
-
Fluoride & Electrocardiogram Abnormalities
An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems
-
Fluoride & Arterial Calcification
The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis
Related FAN Content :
-