Abstract
Brain tissues for neurohistopathological study were obtained at autopsy from albino rabbits that had been subcutaneously injected for 15 weeks with 0, 5, 10, 20, and 50 mg sodium fluoride in 1 mL of aqueous solutions/kg bw/day. Neuropathological changes occurred with loss of the molecular layer and glial cell layer in the brain tissues of rabbits exposed to the three higher fluoride doses. The Purkinje neurones exhibited chromatolysis and acquired a “ballooned” appearance. Nissl substance showed various degrees of decrease and even complete loss. Fragmented particles were retained in the perinuclear zone. The perikaryon showed vacuolization, and spheroid bodies were present in the neoplasm. These cytoplasmic inclusions appeared as various sized ovoid bodies or elongated eosinophilic masses due to which the nucleus was shifted to the periphery. These neurotoxic changes in the brain suggested that there was a direct action of fluoride upon the nerve tissue which was responsible for central nervous system problems such as tremors, seizures, and paralysis indicating brain dysfunction seen at the two highest doses.
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The effect of fluorine on the developing human brain.
Fifteen fetuses from an endemic fluorosis area that were aborted therapeutically at the 5th–8th month of gestation were compared with 16 aborted fetuses from a non-endemic area. Stereological study of the brains showed that the numerical density of the neuron volume and the undifferentiated neuroblasts as well as the nucleus-cytoplasm ratio of the neurons were
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Effects of fluoride in drinking water on NADPH-diaphorase neurons in the forebrain of mice: a possible mechanism of fluoride neurotoxicity
Effects of exposure of Swiss albino adult male mice to 17.6 mg NaF/L in their drinking water for up to 30 days on the NADPH diaphorase (NADPH-d) positive neurons in the forebrain were studied. Histochemical study by the method developed by Hope and Vincent for the distribution of NADPH-d positive neuron cell bodies
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Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat
BACKGROUND: Sodium fluoride (NaF) intoxication is associated with oxidative stress and altered antioxidant defense mechanism. The present study was carried out to evaluate the potential protective role of blackberry and quercetin (Q) against NaF-induced oxidative stress and histological changes in liver, kidney, testis and brain tissues of rats. METHODS: The rats
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Impact of early developmental fluoride exposure on the peripheral pain sensitivity in mice
Consumption of high concentration of fluoride in the drinking water would cause the fluorosis and chronic pain. Similar pain syndrome appeared in the patients in fluoride therapy of osteoporotic. The aim of the current study was to examine whether exposing immature mice to fluoride would modify the peripheral pain sensitivity
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Influence of chronic fluorosis on expression of phospho-Elk-1 in rat brains.
Objective: To investigate the expression and distribution of the downstream substrate of extracellular regulated protein kinase(ERK1/2) pathway, ternary complex factor phospho-Elk-1, in rat brains with chronic fluorosis, and reveal the mechanism of the impaired learning and memory ability caused by chronic fluorosis. Methods: Seventy-two SD rats, weighing 100 - 120 g,
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