Tag: Neurotoxicity
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Iodine Status Modifies the Association between Fluoride Exposure in Pregnancy and Preschool Boys’ Intelligence
References Lu, Y.; Sun, Z.R.; Wu, L.N.; Wang, X.; Lu, W.; Liu, S.S. Effect of High-Fluoride Water on Intelligence in Children. Fluoride 2000, 33, 74–78. [Google Scholar] Xiang, Q.; Liang, Y.; Chen, L.; Wang, C.; Chen, B.; Chen, X.; Zhou, M. Effect of Fluoride in Drinking Water on Children’s Intelligence. Fluoride 2003, 36, 84–94. [Google […]
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Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.
References Adkins and Brunst, 2021 E.A. Adkins, K.J. Brunst Impacts of fluoride neurotoxicity and mitochondrial dysfunction on cognition and mental health: a literature review Int. J. Environ. Res. Public Health, 18 (24) (2021), p. 12884, 10.3390/ijerph182412884 View Record in ScopusGoogle Scholar Blaylock, 2004 R.L. Blaylock Excitotoxicity: A possible central mechanism in fluoride neurotoxicity Fluoride, 37 […]
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Fluoride Induced Neurobehavioral Impairments in Experimental Animals: a Brief Review.
References García MG, Borgnino L (2015) Fluoride in the context of the environment. In: Fluorine: Chemistry, Analysis, Function and Effects, 2015, pp. 3–21. https://doi.org/10.1039/9781782628507-00003 Seixas NS, Cohen M, Zevenbergen B et al (2010) Urinary fluoride as an exposure index in aluminum smelting. AIHAJ 61(1):89–94. https://doi.org/10.1080/15298660008984520 Article Google Scholar Choubisa SL, Choubisa D (2016) Status of industrial […]
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Exposure to environmental neurotoxic substances and neurodevelopment in children from Latin America and the Caribbean.
Introduction Environmental neurotoxicants are pollutants that can negatively affect many cellular metabolic-processes through different pathways: neuroendocrine/thyroid hormone disruption (Pb, methyl-Hg, organochlorines, and polychlorinated biphenyls-PCB), oxidative stress (Pb, methyl-Hg, organochlorines, and chlorpyrifos), dopamine dysfunction (Pb, methyl-Hg, As, chlorpyrifos, pyrethroids, and organochlorines) (Heyer and Meredith, 2017; Rock and Patisaul, 2018). Pistollato et al. (2020) studied neurotoxic substances […]
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Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.
1. Introduction Fluoride is widespread and unevenly distributed in the environment, and it can be rapidly absorbed into the body via water, food, and air (Johnston and Strobel, 2020). Fluoride consumption at the prescribed level is essential for human health, whereas excessive fluoride exposure is harmful to health. Groundwater, minerals, soil, household chemical products such […]
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Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy.
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Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network.
1. Introduction Neurodevelopmental disorders such as impairment of learning and memory, and cognitive dysfunction, are of serious concern due to the health risks and consequences on the developing brain resulting from exposure to exogenous chemicals [1], [2], [3]. The assessment of developmental neurotoxicity (DNT) is not a mandatory requirement in the European Union or the […]
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NaF-induced neurotoxicity via activation of the IL-1B/JNK signaling pathway.
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Weakened interaction of ATG14 and the SNARE complex blocks autophagosome-lysosome fusion contributes to fluoride-induced developmental neurotoxicity.
Highlights NaF induced autophagosome-lysosome fusion blockage. NaF weakened the interaction of ATG14 and SNARE complex. ATG14 regulates the SNARE complex in NaF-induced developmental neurotoxicity. ATG14 upregulation restored autophagosome-lysosome fusion and autophagic flux. ATG14 upregulation protects against developmental fluoride neurotoxicity. Fluoride is capable of inducing developmental neurotoxicity, but the mechanisms involved remain unclear. We aimed to […]
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Impacts of Fluoride Neurotoxicity and Mitochondrial Dysfunction on Cognition and Mental Health: A Literature Review.
Abstract This review focuses on the synthesis of current experimental and observational data regarding the effect of fluoride exposure on childhood mental health and the role of mitochondrial function as a mechanism of action. We aggregated data on the relationships between fluoride neurotoxicity, mitochondrial function, and cognitive and mental health using PubMed. Current animal and […]