Tag: Neurotoxicity
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Weakened interaction of ATG14 and the SNARE complex blocks autophagosome-lysosome fusion contributes to fluoride-induced developmental neurotoxicity.
Highlights NaF induced autophagosome-lysosome fusion blockage. NaF weakened the interaction of ATG14 and SNARE complex. ATG14 regulates the SNARE complex in NaF-induced developmental neurotoxicity. ATG14 upregulation restored autophagosome-lysosome fusion and autophagic flux. ATG14 upregulation protects against developmental fluoride neurotoxicity. Fluoride is capable of inducing developmental neurotoxicity, but the mechanisms involved remain unclear. We aimed to […]
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Impacts of Fluoride Neurotoxicity and Mitochondrial Dysfunction on Cognition and Mental Health: A Literature Review.
Abstract This review focuses on the synthesis of current experimental and observational data regarding the effect of fluoride exposure on childhood mental health and the role of mitochondrial function as a mechanism of action. We aggregated data on the relationships between fluoride neurotoxicity, mitochondrial function, and cognitive and mental health using PubMed. Current animal and […]
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Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis.
For decades, fluoride has been the pre-eminent ingredient in consumer products to prevent dental caries. The evidence that fluoridated toothpaste significantly reduces caries is well documented. 8 , 9 It is now widely accepted that fluoride prevents dental decay by encouraging topical remineralization of early white spot, incipient lesions. New non-fluoride remineralization strategies have emerged […]
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Clofibrate, a PPAR-a agonist, abrogates sodium fluoride-induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba-1/anti-calbindin signaling pathways.
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Effect of hesperidin on fluoride-induced neurobehavioral and biochemical changes in rats.
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Sirt3-mediated mitochondrial dysfunction is involved in fluoride-induced cognitive deficits.
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Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses.
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Dose-response analyses of the 27 human developmental neurotoxicity studies ranked highest quality by National Toxicology Program (NTP) systematic review.
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DNA methylation and fluoride exposure in school-age children: Epigenome-wide screening and population-based validation.
4. Discussion Water-borne endemic fluorosis has been widely prevalent in China, especially in the central, western and northern parts of China. In order to explore the possible epigenetic changes caused by fluoride exposure, we conducted a screening and validation study in step by step. We undertook, for the first time, microarray analyses of DNA methylation […]
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Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride.
3.3. Effects of iAs and F-, alone or in combination, on pathological changesin the hippocampal CA1 region H&E staining of neuron in the hippocampal CA1 region was observed at different optical microscope magnifications (Bar = 100 um 50 um in Fig. 2B & C respectively). In the control group, hippocampal CA1 neurons were tightly organized […]