Tag: Neurotoxicity
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Integrative transcriptome and metabolome analysis of fluoride exposure induced developmental neurotoxicity in mouse brain.
5. Conclusion First, fluoride exposure during pregnancy and lactation may cause neurodevelopmental disorders in the offspring mice, including abnormal expression of genes related to synaptic function, and aneurotransmitters’ accumulation; the magnitude and spectrum of response to fluoride exposure in parents and offspring are significantly different. Second, in mice exposed to fluoride during gestation and lactation, […]
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Association between fluoride exposure in drinking water and cognitive deficits in children: A pilot study.
2.3.1. Children’s drawing tasks A total of 68 (37 males and 31 females) from the 74 children were enrolled and asked to participate in three drawing tasks of common objects that children readily encounter or experience in the study area, though their reproduction varies in complexity: a house, a person, and a donkey. They were […]
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Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.
1. Introduction Fluoride is added to some public water supplies and dental products to prevent dental caries (Community Water Fluoridation, 2019). Drinking water is the largest source of fluoride for children and adults living in fluoridated communities, accounting for 40 %–70 % of daily intake (United States Environmental Protection Agency, n.d.). Black tea is another dietary […]
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Arsenic and fluoride co-exposure through drinking water and their impacts on intelligence and oxidative stress among rural school-aged children of Lahore and Kasur districts, Pakistan.
Discussion … In the present study, a higher frequency of individuals with severe level dental fluorosis was detected in the exposed area. In contrast, none of the individuals in the control area showed signs of dental fluorosis. This was due to the strong correlation of urinary F– with dental fluorosis (R2 = 0.721, Table 2).–… […]
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Iodine Status Modifies the Association between Fluoride Exposure in Pregnancy and Preschool Boys’ Intelligence
References Lu, Y.; Sun, Z.R.; Wu, L.N.; Wang, X.; Lu, W.; Liu, S.S. Effect of High-Fluoride Water on Intelligence in Children. Fluoride 2000, 33, 74–78. [Google Scholar] Xiang, Q.; Liang, Y.; Chen, L.; Wang, C.; Chen, B.; Chen, X.; Zhou, M. Effect of Fluoride in Drinking Water on Children’s Intelligence. Fluoride 2003, 36, 84–94. [Google […]
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Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.
References Adkins and Brunst, 2021 E.A. Adkins, K.J. Brunst Impacts of fluoride neurotoxicity and mitochondrial dysfunction on cognition and mental health: a literature review Int. J. Environ. Res. Public Health, 18 (24) (2021), p. 12884, 10.3390/ijerph182412884 View Record in ScopusGoogle Scholar Blaylock, 2004 R.L. Blaylock Excitotoxicity: A possible central mechanism in fluoride neurotoxicity Fluoride, 37 […]
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Fluoride Induced Neurobehavioral Impairments in Experimental Animals: a Brief Review.
References García MG, Borgnino L (2015) Fluoride in the context of the environment. In: Fluorine: Chemistry, Analysis, Function and Effects, 2015, pp. 3–21. https://doi.org/10.1039/9781782628507-00003 Seixas NS, Cohen M, Zevenbergen B et al (2010) Urinary fluoride as an exposure index in aluminum smelting. AIHAJ 61(1):89–94. https://doi.org/10.1080/15298660008984520 Article Google Scholar Choubisa SL, Choubisa D (2016) Status of industrial […]
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Exposure to environmental neurotoxic substances and neurodevelopment in children from Latin America and the Caribbean.
Introduction Environmental neurotoxicants are pollutants that can negatively affect many cellular metabolic-processes through different pathways: neuroendocrine/thyroid hormone disruption (Pb, methyl-Hg, organochlorines, and polychlorinated biphenyls-PCB), oxidative stress (Pb, methyl-Hg, organochlorines, and chlorpyrifos), dopamine dysfunction (Pb, methyl-Hg, As, chlorpyrifos, pyrethroids, and organochlorines) (Heyer and Meredith, 2017; Rock and Patisaul, 2018). Pistollato et al. (2020) studied neurotoxic substances […]
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Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.
1. Introduction Fluoride is widespread and unevenly distributed in the environment, and it can be rapidly absorbed into the body via water, food, and air (Johnston and Strobel, 2020). Fluoride consumption at the prescribed level is essential for human health, whereas excessive fluoride exposure is harmful to health. Groundwater, minerals, soil, household chemical products such […]
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Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy.