Tag: Neurotoxicity
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A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.
Discussion … The increased precision using the average maternal U-F concentration as an indicator of prenatal fluoride exposure results in stronger statistical evidence of fluoride-associated deficits, compared with using cross-sectional or retrospective studies. Still, the amount of fluoride that reaches the brain during early brain development is unknown, and even the maternal U-F concentration measurements […]
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Fluoride exposure decreased neurite formation on cerebral cortical neurons of SD rats in vitro.
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The safe exposure level to fluoride in pregnancy.
Fluoride (F) is not an essential trace element in humans or necessary for the development of healthy teeth and bones.9,10 It is likely that there is no threshold for fluoride-induced developmental neurotoxicity in drinking water, and the only assuredly safe level of fluoride in drinking water is zero.10,11,12 The currently recommended level of 0.7 mg […]
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Low-moderate fluoride exposure and intelligence among Chinese school-aged children: Role of circulating mtDNA content.
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Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.
References Lin E.P., Lee J.R., Lee C.S., Deng M., Loepke A.W. Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies. Neurotoxicol Teratol. 2017; 60: 117-128. PubMed Jevtovic-Todorovic V., Olney J.W. PRO: anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg. 2008; 106: 1659-1663. PubMed Loepke A.W. McGowan Jr., F.X. […]
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Neurotoxicity in operating room personnel working with gaseous and nongaseous anesthesia.
Excerpt Introduction According to experimental and field studies, exposure to more than 500 ppm of nitrous oxide(N 2O) and more than 15 ppm of haJothane and enflurane can cause performance impairment in neurobehavioral exammations (Bruce and Bach 1975, 1976; Smith and Shirley 1978; Allison et al. 1979; Edling 1980; Mahoney et al. 1988. Control of […]
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Fluoride exposure regulates the elongation phase of protein synthesis in cultured Bergmann glia cells.
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Public-health risks from tea drinking: Fluoride exposure.
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Protective role of maize purple plant pigment against oxidative stress in fluorosis rat brain.
Excerpts 1 Introduction Given the widespread presence of fluorine in the natural environment, individuals are exposed to fluoride via food intake, inhalation, and dermal contact. Drinking water represents the largest exposure source. In particular, in highly fluoridated regions and in some developed areas that fluoridate the public water supply to reduce dental caries, fluoride may […]
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Predictors of Plasma Fluoride Concentrations in Children and Adolescents.
Funding This research was funded by NATIONAL INSTITUTES OF HEALTH, grant numbers K23ES024803 and R01ES030101 and the Maine Economic Improvement Fund. Conflicts of Interest The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the […]