Sunday, August 22nd, 2021

Dose-response analyses of the 27 human developmental neurotoxicity studies rankehighest quality by National Toxicology Program (NTP) systematic review.

Sunday, August 8th, 2021

DNA methylation and fluoride exposure in school-age children: Epigenome-wide screening and population-based validation.

4. Discussion Water-borne endemic fluorosis has been widely prevalent in China, especially in the central, western and northern parts of China. In order to explore the possible epigenetic changes caused by fluoride exposure, we conducted a screening and validation study in step by step. We undertook, for the first time, microarray analyses of DNA methylation […]

Monday, July 12th, 2021

Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride.

3.3. Effects of iAs and F-, alone or in combination, on pathological changesin the hippocampal CA1 region H&E staining of neuron in the hippocampal CA1 region was observed at different optical microscope magnifications (Bar = 100 um 50 um in Fig. 2B & C respectively). In the control group, hippocampal CA1 neurons were tightly organized […]

Wednesday, June 9th, 2021

A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.

Discussion … The increased precision using the average maternal U-F concentration as an indicator of prenatal fluoride exposure results in stronger statistical evidence of fluoride-associated deficits, compared with using cross-sectional or retrospective studies. Still, the amount of fluoride that reaches the brain during early brain development is unknown, and even the maternal U-F concentration measurements […]

Thursday, May 20th, 2021

Fluoride exposure decreased neurite formation on cerebral cortical neurons of SD rats in vitro.

Monday, May 10th, 2021

The safe exposure level to fluoride in pregnancy.

Fluoride (F) is not an essential trace element in humans or necessary for the development of healthy teeth and bones.9,10 It is likely that there is no threshold for fluoride-induced developmental neurotoxicity in drinking water, and the only assuredly safe level of fluoride in drinking water is zero.10,11,12 The currently recommended level of 0.7 mg […]

Saturday, May 1st, 2021

Low-moderate fluoride exposure and intelligence among Chinese school-aged children: Role of circulating mtDNA content.

Tuesday, March 30th, 2021

Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.

References Lin E.P., Lee J.R., Lee C.S., Deng M., Loepke A.W. Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies. Neurotoxicol Teratol. 2017; 60: 117-128. PubMed Jevtovic-Todorovic V., Olney J.W. PRO: anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg. 2008; 106: 1659-1663. PubMed Loepke A.W. McGowan Jr., F.X. […]

Monday, March 29th, 2021

Neurotoxicity in operating room personnel working with gaseous and nongaseous anesthesia.

Excerpt Introduction According to experimental and field studies, exposure to more than 500 ppm of nitrous oxide(N 2O) and more than 15 ppm of haJothane and enflurane can cause performance impairment in neurobehavioral exammations (Bruce and Bach 1975, 1976; Smith and Shirley 1978; Allison et al. 1979; Edling 1980; Mahoney et al. 1988. Control of […]

Monday, March 22nd, 2021

Fluoride exposure regulates the elongation phase of protein synthesis in cultured Bergmann glia cells.