Abstract
Twenty-one-day old weanling albino rats were divided into paired control and experimental groups, both of which were given ad libitum supplies of rat cake diet and drinking water (fluoride ion content 0·2-0·3 p.p.m.). The drinking water of the experimental groups was supplemented by the addition of sodium flJioride to give fluoride ion concentrations of 10,
25′, 100, 250 and 500 p.p.m. Mter periods varying from 13 to 52 weeks paired control and experimental animals were killed and the femurs removed, dissected free of connective tissue and radiographed.
The breaking stress and deflexion of the femurs on bending were determined within 5 hr of removal by the method of Bell, Cuthbertson & Orr (1941). The bones were then ashed and their inorganic residue determined.
All animals thrived and there was no difference in the pattern of weight gain between the experimental animals and their controls, with the exception of those drinking 500 p.p.m. These animals soon developed toxic signs and all died within 1 week.
The results show that, in rats, consumption of drinking water with a fluoride ion content as high as 250 p.p.m. for up to 52 weeks has no effect upon the radiographic appearance, the breaking stress and deflexion pattern on bending and the ash content.
-
-
On fluoride and bone strength
The recent paper by Einhorn et al. [1] drew the conclusion that fluoride incorporation into bone does not impair bone's mechanical properties. This result is in conflict with the results of others concerning fluoride and bone strength. For instance, several investigators--including ourselves--have shown that bone strength decreases as bone fluoride
-
The effect of NaF in vitro on the mechanical and material properties of trabecular and cortical bone
[T]he elastic modulus measured in cortical bone using the BDI and the Oliver-Parr method decreased significantly after NaF [sodium fluoride] treatment, compared to control measurements prior to NaF treatment . . . . The general finding of the previous papers was that NaF reduces cortical-bone strength and elastic modulus, which is
-
The effect of fluoride supplementation on the strength of osteopenic bone
The strength of osteopenic bone from calcium deprived rats, quail and roosters was significantly reduced after fluoride supplementation. Using a device which measures torque, femurs from rats fed low calcium diets with 100 parts per million fluoride added to the water supply fractured at lower torque values than those values
-
Effect of dietary fluorine on growth, blood and bone characteristics of growing-finishing pigs
Three hundred eighty-four growing-finishing pigs were used in two experiments to determine the effect of dietary fluorine (F) on growth, blood and bone physical characteristics. Fourteen dietary treatments were formulated by supplementing F (as NaF) to a milo-soybean meal basal diet (7 ppm F) to provide levels of 7, 132,
-
Treatment of osteoporosis with sodium fluoride: An appraisal.
Crippling fluorosis... is characterized by dense bones, exostoses, neurologic complications due to bony overgrowth, osteoarthritis, and ligamentous calcification. ... new bone formed under the stimulus of fluoride administration may exhibit various degrees of osteosclerosis, osteoporosis, osteomalacia, and architectural disorganization. Of these manifestations, only osteosclerosis increases bone strength. When fluoride is used
Related Studies :
-
-
-
Fluoride Reduces Bone Strength Prior to Onset of Skeletal Fluorosis
The majority of animal studies investigating fluoride's impact on bone strength have found that fluoride has either no effect, or a detrimental effect, on bone strength. Importantly, several of the animal studies that have found fluoride reductes bone strength have reported that this reduction in strength occurs before signs of skeletal fluorosis
-
Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
-
Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
-
The Relationship Between Fluoride, Bone Density, and Bone Strength
Although fluoride has generally been found to reduce the bone density of cortical bone, it is well documented that fluoride can increase the density of trabecular bone (aka cancellous bone). Trabecular bone is the primary bone of the spine, whereas cortical bone is the primary bone of the legs and arms. While increases in
-
In Vitro Studies on Fluoride & Bone Strength
The "in vitro" research on fluoride and bone strength confirms what has repeatedly been found in animal and human studies: the more fluoride a bone has, the weaker the bone becomes. In an in vitro bone study, the researcher directly exposes a human or animal bone to a fluoride solution
Related FAN Content :
-