Abstract
Twenty-one-day old weanling albino rats were divided into paired control and experimental groups, both of which were given ad libitum supplies of rat cake diet and drinking water (fluoride ion content 0·2-0·3 p.p.m.). The drinking water of the experimental groups was supplemented by the addition of sodium flJioride to give fluoride ion concentrations of 10,
25′, 100, 250 and 500 p.p.m. Mter periods varying from 13 to 52 weeks paired control and experimental animals were killed and the femurs removed, dissected free of connective tissue and radiographed.
The breaking stress and deflexion of the femurs on bending were determined within 5 hr of removal by the method of Bell, Cuthbertson & Orr (1941). The bones were then ashed and their inorganic residue determined.
All animals thrived and there was no difference in the pattern of weight gain between the experimental animals and their controls, with the exception of those drinking 500 p.p.m. These animals soon developed toxic signs and all died within 1 week.
The results show that, in rats, consumption of drinking water with a fluoride ion content as high as 250 p.p.m. for up to 52 weeks has no effect upon the radiographic appearance, the breaking stress and deflexion pattern on bending and the ash content.
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Fluoride treatment increased serum IGF-1, bone turnover, and bone mass, but not bone strength, in rabbits
We hypothesized that fluoride partly acts by changing the levels of circulating calcium-regulating hormones and skeletal growth factors. The effects of oral fluoride on 24 female, Dutch-Belted, young adult rabbits were studied. The rabbits were divided into two study groups, one control and the other receiving about 16 mg fluoride/rabbit/day
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The impact of fluoride in drinking water on oral health and skeletal system of school children
Modern life styles even among people in rural areas have created an increased demand for dental cosmetology. Dental fluorosis due to its cosmetic effect gains more public health importance today. In the scenario of increasing awareness of environmental health hazards, among people, the research into the biology of fluorosis conducted
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The effects of sodium fluoride on bone breaking strength
The therapeutic use of sodium fluoride has been recommended in a variety of osteopenic bone diseases. The recommendations are based mainly on the known osteosclerotic effects of sodium fluoride and little information is available as to its effect on bone strength. The influence of various concentrations of sodium fluoride on
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The effect of fluoride supplementation on the strength of osteopenic bone
The strength of osteopenic bone from calcium deprived rats, quail and roosters was significantly reduced after fluoride supplementation. Using a device which measures torque, femurs from rats fed low calcium diets with 100 parts per million fluoride added to the water supply fractured at lower torque values than those values
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Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease.
Minimal trauma fractures in bone diseases are the result of bone fragility. Rather than considering bone fragility as being the result of a reduced amount of bone, we recognize that bone fragility is the result of changes in the material and structural properties of bone. A better understanding of the
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Skeletal Fluorosis: The Misdiagnosis Problem
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"Pre-Skeletal" Fluorosis
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In Vitro Studies on Fluoride & Bone Strength
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