Abstract
As part of a 2002-2003 investigation on the effects of high fluoride drinking water on IQ scores of children, serum fluoride (F) levels in the children were subjected to further study. Among the new findings, although IQ scores of boys and girls differed in the seven IQ level categories, there were no overall gender differences (boy/girl ratio 1.220 vs. 1.214 in the high and low F villages, respectively). However, the mean IQ was significantly higher and there were fewer children with an IQ less than 80 in the two quartiles with a serum fluoride level of less than 0.05 mg F/ L. Analysis of the overall relationship between IQ scores and serum F levels indicates there may be no serum F level below which adverse effects on IQ might not be present.
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Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies.
Background Fluoride may be a developmental neurotoxicant at elevated exposures. We merged new data from a prospective [Danish] Odense Child Cohort (OCC) with results from two previous birth cohort studies from Mexico and Canada to characterize the dose–effect relationship in greater detail. Methods The OCC contributed 837 mother–child pairs to the total of
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Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?
Background: Excessive exposure to fluoride can reduce intelligence. Methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 (MTHFD1) polymorphisms have important roles in neurodevelopment. However, the association of MTHFD1 polymorphisms with children's intelligence changes in endemic fluorosis areas has been rarely explored. Methods: A cross-sectional study was conducted in four randomly selected primary schools in
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Studies of relationships between the polymorphism of COMT gene and plasma proteomic profiling and children’s intelligence in high fluoride areas
Part I – Effect of high F drinking water on children’s IQ Objective: To investigate the relationships among the children’s serum F, urine F, thyroid hormone levels and children’s IQ in the high fluoride areas. Methods: We collected the samples of the drinking water, urine and blood and measured the F concentrations,
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The relationship of a low-iodine and high-fluoride environment to subclinical cretinism in Xinjiang.
Cretinism in iodine-deficiency areas is well known, yet the milder forms of somatic and psychomotor maldevelopment and thyroid dysfunction caused by iodine deficiency may be more difficult to detect. DeQuervain, in 1936, called this milder form "semi-cretinism," while in 1980 Laggasse used the term "cretinoidism." It was formally named "subclinical
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The cognitive impairment and risk factors of the older people living in high fluorosis areas: DKK1 need attention.
Objective To evaluate cognitive impairment and risk factors of elders in high fluoride drinking water areas and investigate whether DKK1 is involved in this disorder. Methods MoCA-B and AD-8 were used to measure the cognitive functions of 272 and 172 subjects over the age of 60 came from the high and normal fluoride drinking
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Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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