Abstract
Exposure to 5 mg HF/m3 causes a significant increase in the plasma cholesterol levels in the guinea pig. Modifications of the cholesterol metabolism are due to the specific action of fluoride. Effects of HF on cholesterolemia are reversible however, and during a second exposure to HF, plasma cholesterol increases as in the first exposure. Cholesterol biosynthesis was studied, Acetate incorporation in intestinal tissue and lung was higher in intoxicated animals than in controls but mevalonate incorporation was comparable in the two groups. The enzyme catalyzing mevalonate synthesis, 8-methyl-8-hydroxyglutaryl CoA reductase, could be activated by HF.
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Fluoride enhances generation of reactive oxygen and nitrogen species, oxidizes hemoglobin, lowers antioxidant power and inhibits transmembrane electron transport in isolated human red blood cells.
Highlights NaF enhances generation of ROS and RNS in human RBC. It oxidizes hemoglobin to give methemoglobin and oxyferryl hemoglobin. NaF impairs the antioxidant power of cells. It inhibits the pathways of glucose metabolism. NaF inhibits transmembrane electron transport system. Fluoride is a widespread environmental pollutant that at high levels
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Effect of chronic exposure to sodium fluoride and 7,12- dimethylbenz[a]anthracene on some blood parameters and hepatic, renal, and cardiac histopathology in rats.
This study aimed to investigate the effects of both sodium fluoride (NaF) and 7,12-dimethylbenz[a]anthracene (DMBA), both separately and in combination, on some blood parameters and hepatic, renal, and cardiac histopathology in rats. Forty male Wistar albino rats, weighing 250–300 g, were randomly divided into one control and three experimental groups
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Effect of inhaled waste anaesthetic gas on blood and liver parameters among hospital staff.
A significant health risk exists within a section of health workers that are exposed to anaesthetic gas and vapours, found in the atmosphere of treatment or operating rooms. These compounds are classified as waste anaesthetic gases (WAG). The present study aimed at identifying alterations in hepatic and haematological parameters occurring
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Relationship between fluoride and bone metabolism: focusing on serum ionic fluoride concentrations.
Fluoride is ubiquitous in the environment. Fluoride are contained in air, soil, water, plants and animals. Human, therefore, intakes fluoride from air, drinking water and foods throughout the life. The fluoride absorption from gastrointestinal tract is rapid and complete in the absence of calcium, magnesium and aluminum. About 40 to
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Effects of fluoride on the tissue oxidative stress and apoptosis in rats: biochemical assays supported by IR spectroscopy data.
The mechanism underlying the toxicity of fluoride still remains unknown. To investigate the effects of different doses of fluoride on blood and tissue oxidative stress and apoptosis, we exposed male rats to three doses of fluoride (10, 50 and 100ppm in drinking water) for a period of 10 weeks. The
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