Abstract

Exposure to 5 mg HF/m3 causes a significant increase in the plasma cholesterol levels in the guinea pig. Modifications of the cholesterol metabolism are due to the specific action of fluoride. Effects of HF on cholesterolemia are reversible however, and during a second exposure to HF, plasma cholesterol increases as in the first exposure. Cholesterol biosynthesis was studied, Acetate incorporation in intestinal tissue and lung was higher in intoxicated animals than in controls but mevalonate incorporation was comparable in the two groups. The enzyme catalyzing mevalonate synthesis, 8-methyl-8-hydroxyglutaryl CoA reductase, could be activated by HF.

• Related Studies :

  • Investigations of soft tissue functions in fluorotic individuals of North Gujurat

    The present study was undertaken to investigate the various health problems caused by water-borne fluoride in endemic villages of Mehsana and Banaskantha districts of Gujarat. The study revealed high levels of fluoride in serum samples of the villagers. Mottling of teeth and skeletal complications were common. Intake of fluoride caused

  • Haematological alterations induced by subchronic oral exposure of buffalo calves to fipronil and fluoride.

    A study is reported on haematological alterations in buffalo calves from subchronic oral exposure to the pesticide fipronil, sodium fluoride alone, and the two in combination. Twenty-four male buffalo calves, 6 to 12 months old, were divided into 4 groups of 6 animals each. Group I without treatment served as

  • Water-borne fluoride and primary hypertension.

    Despite mixed results with laboratory animals, recent studies indicate that elevated intake of fluoride in drinking water may, depending on circumstances, cause high blood pressure (hypertension) in humans. Although primary or essential hypertension has various causes and is known to be associated with higher levels of vasoconstrictors like endothelin 1

  • In vitro protective role of melatonin against hemolysis induced by sodium fluoride in human red blood tests.

    This study was designed to evaluate the protective effect of melatonin against in vitro hemolysis induced by fluoride (F) in human red blood cells. Venous blood samples from twenty healthy, well-nourished male donors, age 20–25, residing in a nonfluorotic area of Ahmedabad, India, were collected for the preparation of red

  • Association between fluoride exposure and blood pressure in children and adolescents aged 6 to19 years in the United States: NHANES, 2013–2016.

    Highlights An inverse association was observed between water fluoride and childhood BP. Association between water fluoride and BP showed discrepancies in sex, age, arace. A negative association was found between plasma fluoride and BP only in other races. To examine the association between fluoride exposure and childhood blood pressure (BP), we