Abstract

Exposure to 5 mg HF/m3 causes a significant increase in the plasma cholesterol levels in the guinea pig. Modifications of the cholesterol metabolism are due to the specific action of fluoride. Effects of HF on cholesterolemia are reversible however, and during a second exposure to HF, plasma cholesterol increases as in the first exposure. Cholesterol biosynthesis was studied, Acetate incorporation in intestinal tissue and lung was higher in intoxicated animals than in controls but mevalonate incorporation was comparable in the two groups. The enzyme catalyzing mevalonate synthesis, 8-methyl-8-hydroxyglutaryl CoA reductase, could be activated by HF.

• Related Studies :

  • Diverse effects of fluoride on NA+ and K+ transport across the rat erythrocyte membrane.

    The cellular effects of fluoride (as F – from NaF) on Na + and K + transport across the rat erythrocyte membrane were investigated using 22 Na as a tracer and nonradioactive Rb + as a K + congener. Exposure of rat erythrocytes to 20 mM NaF for 30–120 min

  • Histopathology and cell cycle alteration in the spleen of mice from low and high doses of sodium fluoride.

    Administration of sodium fluoride (NaF) in lower (15 mg/L) and higher (150 mg/L) doses through drinking water for 30 or 90 days in Swiss albino mice resulted in a decrease in the organo-somatic index (OSI) accompanied by a decline in the white pulp content of the spleen. The percentage of

  • Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency

    Excessive fluoride consumption leads to accelerated red blood cell death and anaemia. Whether that increases the haematological alteration in subjects with haematological disorders (iron deficiency, thalassaemia, and G-6-PD deficiency) is still unclear. The fluoride in serum and urine and haematological parameters of students at Mae Tuen School (fluoride endemic area)

  • Fluoride-induced hyperkalemia: the role of Ca2+-dependent K+ channels.

    Acute fluoride poisoning is associated with sudden cardiac death by an unknown mechanism. Because F- binds to Ca2+ to cause marked hypocalcemia, lowered serum Ca2+ concentrations have been thought to be a major underlying factor in the ventricular irritability of F(-)-toxic patients. However, correction of the hypocalcemia does not prevent

  • Effects of addition of fluorine in diets differing in protein content on urinary fluoride excretion, clinical chemistry and thyroid hormones in calves

    In order to compare the effects of addition of fluorine (F) in diets differing in protein content on the urinary F excretion, blood profile and thyroid hormones, 30 crossbred calves (6-8 months) initially exposed to different protein levels were allotted into six groups in a 3 × 2 factorial design. The factors