Abstract

Exposure to 5 mg HF/m3 causes a significant increase in the plasma cholesterol levels in the guinea pig. Modifications of the cholesterol metabolism are due to the specific action of fluoride. Effects of HF on cholesterolemia are reversible however, and during a second exposure to HF, plasma cholesterol increases as in the first exposure. Cholesterol biosynthesis was studied, Acetate incorporation in intestinal tissue and lung was higher in intoxicated animals than in controls but mevalonate incorporation was comparable in the two groups. The enzyme catalyzing mevalonate synthesis, 8-methyl-8-hydroxyglutaryl CoA reductase, could be activated by HF.

• Related Studies :

  • Environmental Fluoride 1977 by Rose & Marier

    The Associate Committee on Scientific Criteria for Environmental Quality was established by the National Research Council of Canada in response to a mandate provided by the Federal Government to develop scientific guidelines for defining the quality of the environment. The concern of the NRC Associate Committee is strictly with scientific

  • Excessive fluoride consumption leads to accelerated death of erythrocytes and anemia in rats.

    The present study was performed to evaluate an overall effect of long-term consumption of excessive fluoride (F) amounts by rats on their erythrocytes. The animals were administered regular drinking water (0.4 ppm F) or the same water supplemented with 2, 10, and 20 ppm F (as NaF) for 12 months. Chronic exposure of

  • Changes in the concentration of fluoride in the serum and bones of female rats with streptozotocin induced diabetes.

    The aim of this study was to determine if streptozotocin-induced diabetes in rats as a model for Type-1 human diabetes causes changes in the levels of fluoride (F) and biogenic elements in the bones and serum in the initial stage of the disease. Twenty-two female Wistar rats were given streptozotocin

  • Histopathology and cell cycle alteration in the spleen of mice from low and high doses of sodium fluoride.

    Administration of sodium fluoride (NaF) in lower (15 mg/L) and higher (150 mg/L) doses through drinking water for 30 or 90 days in Swiss albino mice resulted in a decrease in the organo-somatic index (OSI) accompanied by a decline in the white pulp content of the spleen. The percentage of

  • Long-term exposure to low level of fluoride induces apoptosis via p53 pathway in lymphocytes of aluminum smelter workers.

    Long-term occupational exposure to low level of fluoride can induce oxidative stress and apoptosis in many cells, including lymphocyte. However, the underlying mechanism remains unclear. Hence, this study was designed to explore the potential oxidative stress and apoptosis of long-term occupational exposure to low level of fluoride in aluminum smelter