Abstract
Intraperitonial administration of 10 mg fluoride (NaF)/kg body weight resulted in hyperglycemia in rats. Role of gluconeogenesis and glycogenolysis in this hyperglycemic response was evaluated. Results of the study indicate that the fluoride induced hyperglycemia is mainly due to increased hepatic glycogenolysis.
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Ameliorative effect of tamarind leaf on fluoride-induced metabolic alterations
OBJECTIVES: Fluoride is a serious health hazard across several nations, and chronic intake of fluoride deranges the carbohydrate, lipid and antioxidant metabolism in general. As there are limited remedial measures to prevent fluorosis, we investigated the role of tamarind leaf as a food supplement in restoration of carbohydrate, lipid and
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Influence of extended exposure to sodium fluoride and caffeine on the activity of carbohydrate metabolism enzymes in rat blood serum and liver.
A 50-day study of the influence of fluoride (F) and caffeine on carbohydrate metabolism enzymes was conducted on 18 male Sprague-Dawley rats, 4.5 months old, housed in separate cages at 22–25°C on a 12-hr light/dark cycle. The rats were divided into three groups with six rats in each group: control,
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Influence of NaF and Na2PO3F(MFP) on glucose metabolism in rat hepatocytes.
Addition of NaF or MFP to rat hepatocytes resulted in a decrease in lactate and in an increase in glucose, 3 and 2-phosphoglycerate production. When dihydroxyacetone was present in the incubation medium both NaF and MFP increased the production of glucose, fructose-1,6-diphosphate, 3 and 2 phosphoglycerate, with a decrease in
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Sodium fluoride induced histopathalogical changes in liver and kidney of albino mice.
Fluoride is a well determined non-biodegradable and moderate pollutant, which at high levels causes serious health problems. The present study was designed to investigate the histopathalogical changes in liver and kidney of exposure to sodium fluoride in albino mice. Eighteen adult albino mice were divided into 3 groups (6 mice
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Adenyl cyclase activity following fluoride ingestion.
Adenyl cyclase activity and fluoride content were investigated in various tissues of adult rabbits given NaF (10 mg/kg body wt./day) orally for 6 months. The activity of adenyl cyclase increased significantly in bone, liver, and kidney, whereas it was unchanged in skeletal muscle following fluoride ingestion. The levels of fluoride
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