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Adding fluoride to water supply may have no benefit, say experts
Critics call for end to scheme designed to prevent tooth decay in children, saying its effectiveness remains unproved Water fluoridation has been in place in England for more than 40 years, and now covers about 6 million people. The US Centers for Disease Control and Prevention calls adding fluoride to drinking water one of the […]
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Sodium fluoride induces apoptosis through the downregulation of hypoxia-inducible factor-1a in primary cultured rat chondrocytes
Results of previous studies have shown that fluoride has a higher and special affinity for calcium in bone tissue, which could result in osteofluorosis (19,20). It has been reported that osteofluorosis may increase the severity of osteoarthritis (OA) characterized by progressive degeneration of articular cartilage (21,22). Chondrocyte apoptosis may be involved in the onset and […]
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Rachitomimetic effects of fluoride feeding on the skeletal tissues of growing pigs
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Developmental neurotoxicity of fluoride: a quantitative risk analysis toward establishing a safe daily dose of fluoride for children
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Human studies on Fluoride’s Neurotoxicity
U.S. agencies funding the studies: NIH (National Institute of Heath). The NIEHS and the NIDCR come under the aegis of the NIH. NIEHS (National Institute of Environmental Health Sciences) has responsibility for the NTP (National Toxicology Program). The NIEHS is the research arm of U.S. regulatory agencies. The NTP is best known for its Reports […]
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Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.
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Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.
References Lin E.P., Lee J.R., Lee C.S., Deng M., Loepke A.W. Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies. Neurotoxicol Teratol. 2017; 60: 117-128. PubMed Jevtovic-Todorovic V., Olney J.W. PRO: anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg. 2008; 106: 1659-1663. PubMed Loepke A.W. McGowan Jr., F.X. […]
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Probiotic alleviate fluoride-induced memory impairment by reconstructing gut microbiota in mice.
1. Introduction Fluoride is a widespread environmental pollution, and groundwater is the major source of exposure in which the fluoride concentration can be as high as 35 ppm (Petrone et al., 2013). Fluorosis induced by geological origin is a serious public health concern in 28 nations particularly in India and China (Rafique et al., 2015). In […]
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Exposure to environmental neurotoxic substances and neurodevelopment in children from Latin America and the Caribbean.
Introduction Environmental neurotoxicants are pollutants that can negatively affect many cellular metabolic-processes through different pathways: neuroendocrine/thyroid hormone disruption (Pb, methyl-Hg, organochlorines, and polychlorinated biphenyls-PCB), oxidative stress (Pb, methyl-Hg, organochlorines, and chlorpyrifos), dopamine dysfunction (Pb, methyl-Hg, As, chlorpyrifos, pyrethroids, and organochlorines) (Heyer and Meredith, 2017; Rock and Patisaul, 2018). Pistollato et al. (2020) studied neurotoxic substances […]
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The safe exposure level to fluoride in pregnancy.
Fluoride (F) is not an essential trace element in humans or necessary for the development of healthy teeth and bones.9,10 It is likely that there is no threshold for fluoride-induced developmental neurotoxicity in drinking water, and the only assuredly safe level of fluoride in drinking water is zero.10,11,12 The currently recommended level of 0.7 mg […]