Abstract

In an endemic fluorosis area, 16 fetuses that were delivered during their sixth to eighth month of gestation by means of artificial abortion were collected and studied. The results [compared to 10 control fetuses from a non-endemic area] show that fluorine levels in tissues are obviously high, especially in brain, calvarium, and femur. The activity of alkaline phosphatase in femur and kidney was raised. By observation of the ultrastructure of samples, the number of mitochondria, rough-surfaced endoplasmic reticulum, and free ribosome in neurons of cerebral cortex were reduced, and the rough-surfaced endoplasmic reticulum was obviously dilated. These findings indicate that the neurons of the cerebral cortex in the developing brain may be one of the targets of fluorine.

Translated by Julian Brooke for Fluoride Action Network and published with the permission of the Chinese Journal of Control of Endemic Diseases 1989;4(3):136-8 in the journal Fluoride.

• Related Studies :

  • [Effects of sodium fluoride on the activity of Ca2+Mg(2+)-ATPase in synaptic membrane in rat brain].

    Effects of sodium fluoride on Ca2+Mg(2+)-ATPase activity of synaptic membrane in rat brain were studied with in vitro or in vivo methods. Concentrations of sodium fluoride of 0.3, 1.6, 8.0, 20.0 and 40.0 mmol/L can significantly inhibit the activity of the enzyme with proportions of 6.6%, 18.0%, 41.0%, 55.5% and

  • Determination of the contents of amino-acid and monoamine neurotransmitters in fetal brains from a fluorosis-endemic area.

    The contents of five types of amino-acid neurotransmitters and three types of monoamine neurotransmitters in the brains of fetuses aborted through induced labor in a chronic fluorosis-endemic area were determined.  Findings revealed that the content of the excitatory amino acid, aspartic acid, was significantly lower than in the fetuses from

  • The effect of fluorine on the developing human brain.

    Fifteen fetuses from an endemic fluorosis area that were aborted therapeutically at the 5th–8th month of gestation were compared with 16 aborted fetuses from a non-endemic area. Stereological study of the brains showed that the numerical density of the neuron volume and the undifferentiated neuroblasts as well as the nucleus-cytoplasm ratio of the neurons were

  • Behavioral teratology in rats exposed to fluoride.

    A study was conducted of behavioral differences in Wistar rat pups born of dams drinking water containing 1.0, 5.0, and 25 mg F/L from the day of conception. A control group drank tap water containing 0.6 mg F/L. Among 18 litters in the 25 mg/L group, four of the dams

  • Neurotransmitter and receptor changes in the brains of fetuses from areas of endemic fluorosis.

    The levels of neurotransmitters and receptors in brain tissue of aborted fetuses from areas of endemic fluorosis were tested. The results showed that in 10 fetuses from a high fluoride area ranging in age from 5 to 7 months, the levels of norepinephrine, 5-hydroxytryptamine, and a1-receptor were lower, and the level of epinephrine was higher as compared with levels

• Related FAN Content :

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

  • Fluoride Gels & Kidney Function

    Scientists have found that the application of "Fluoride Gels" at the dental office causes very high spikes in the blood fluoride level. The high spikes in blood fluoride levels are a result of three factors: the high concentration of fluoride in the gel (= 12.3 mg of fluoride in each

  • Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence

    A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.