Abstract
The effects of excessive fluoride intake during pregnancy on neonatal neurobehavioral development and the neurodevelopment toxicity of fluoride were evaluated. Ninety-one normal neonates delivered at the department of obstetrics and gynecology in five hospitals of Zhaozhou County, Heilongjiang Province, China were randomly selected from December 2002 to January 2003. The subjects were divided into two groups (high fluoride and control) based on the fluoride content in the drinking water of the pregnant women. The results showed that the urinary fluoride levels of mothers from the high fluoride group were higher than those of the control group. There were significant differences in the neonatal behavioral neurological assessment score and neonatal behavioral score between the subjects in the endemic fluoride areas and the control group. There were also significant differences in the non-biological visual orientation reaction and biological visual and auditory orientation reaction between the two groups. It is concluded that fluoride is toxic to neurodevelopment and that excessive fluoride intake during pregnancy can cause adverse effects on neonatal neurobehavioral development.
Translated by Bin Li for Fluoride Action Network and published with the concurrence of the Chinese Journal of Endemiology 2004 Sep;23(5):463-5 in the journal Fluoride.
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Systematic review of epidemiological and toxicological evidence on health effects of fluoride in drinking water.
Introduction Fluoride is a naturally occurring substance that is also added to drinking water, dental hygiene products, and food supplements for preventing dental caries. Concerns have been raised about several other potential health risks of fluoride. Objective To conduct a robust synthesis of evidence regarding human health risks due to exposure to fluoride
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Expert panel meeting on the health effects of fluoride in drinking water: Summary report.
Notes: While the pdf of this report is attached, the summary below is dated June 8-9, 2023 and modified on February 6, 2024. It is online at https://www.canada.ca/en/health-canada/services/environmental-workplace-health/reports-publications/water-quality/expert-panel-meeting-effects-fluoride-drinking-summary.html This report pertains to the Expert Panel for the February 6, 2024, report titled: Systematic review of epidemiological and toxicological evidence on health effects of
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Influence of chronic fluorosis on expression of phospho-Elk-1 in rat brains.
Objective: To investigate the expression and distribution of the downstream substrate of extracellular regulated protein kinase(ERK1/2) pathway, ternary complex factor phospho-Elk-1, in rat brains with chronic fluorosis, and reveal the mechanism of the impaired learning and memory ability caused by chronic fluorosis. Methods: Seventy-two SD rats, weighing 100 - 120 g,
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The relationships between thyroid-stimulating hormone and/or dopamine levels in peripheral blood and IQ in children with different urinary iodine concentrations.
Highlights TSH is not related IQ in children with different urinary iodine concentrations. Dopamine in plasma is unrelated to IQ in children with adequate or excessive iodine. Dopamine has positive correlation with intelligence in iodine deficiency group. The interaction between dopamine in plasma and TSH is not related to
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Fluoride exposure and children’s intelligence: Gene-environment interaction based on SNP-set, gene and pathway analysis, using a case-control design based on a cross-sectional study.
Highlights High intelligence was inversely correlated with water, urinary, hair and nail fluoride. Fluoride interacts with a SNP-set of rs3788319, rs1879417, rs57377675, rs11556505 and rs7187776 on intelligence. Fluoride interacts with mitochondrial function-related genes CLU and TOMM40 on intelligence. Multiple neurodevelopmental pathways related to metabolism may be involved in the
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Fluoride Affects Learning & Memory in Animals
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
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