Abstract
In a new approach to an understanding of the genesis of nonskeletal and skeletal fluorosis, glutathione content in blood was investigated. Thirty cases of fluorosis and forty controls (20 from fluorotic and 20 from nonfluorotic areas) were studied. In fluorotic subjects, blood glutathione concentration was significantly elevated. Urinary hydroxyproline and serum alkaline phosphatase data were also correlated. It appears that the persistent stress of the F- ion demands a protective redox maintainer and that glutatione fulfills that need.
-
-
Oxidative stress parameters in rats exposed to fluoride and aspirin.
The action of fluoride (F) and aspirin (acetylsalicylic acid, ASA) administered separately and together on oxidative stress parameters and on F excretion in rats was studied over a period of six weeks. Thirty adult male Wistar rats were divided into five equal groups of six each: (I) controls receiving tap
-
AMPK/p38/Nrf2 activation as a protective feedback to restrain oxidative stress and inflammation in microglia stimulated with sodium fluoride.
Highlights NaF-stimulated redox imbalance and inflammation. NaF activated the Nrf2 signaling in BV-2 cells and primary cultured microglia. Nrf2 activation exerts a neuroprotective effect on NaF-stimulated redox imbalance and inflammation. ROS-AMPK-p38 signaling is the upstream signaling pathway involved in NaF-induced Nrf2 activation. Dysregulated activation of inflammation plays an important role in the
-
Ameliorative effect of tamarind leaf on fluoride-induced metabolic alterations
OBJECTIVES: Fluoride is a serious health hazard across several nations, and chronic intake of fluoride deranges the carbohydrate, lipid and antioxidant metabolism in general. As there are limited remedial measures to prevent fluorosis, we investigated the role of tamarind leaf as a food supplement in restoration of carbohydrate, lipid and
-
Ameliorative effects of quercetin on sodium fluoride-induced oxidative stress in rat's kidney
OBJECTIVE: The in vivo nephroprotective effect of quercetin against sodium fluoride (NaF)-induced damage was studied. METHODS: Renal injury was induced by daily administration of NaF (600 ppm) through drinking water for 1 week. The levels of reduced glutathione (GSH), lipid peroxidation as well as superoxide dismutase and catalase activity of
-
Effects of Perinatal Fluoride Exposure on Short- and Long-Term Memory, Brain Antioxidant Status, and Glutamate Metabolism of Young Rat Pups.
Exposure to fluoride (F) during the development affects central nervous system of the offspring rats which results in the impairment of cognitive functions. However, the exact mechanisms of F neurotoxicity are not clearly defined. To investigate the effects of perinatal F exposure on memory ability of young rat offspring, dams
Related Studies :
-
-
-
Fluoride & Oxidative Stress
A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. It is also well established that fluoride's toxic effects can be ameliorated by exposure
-
Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
-
Fluoride content in tea and its relationship with tea quality.
J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected
Related FAN Content :
-