Abstract
The neurotoxic effect of fluoride on lipid content of brain was assessed in rabbits during experimental fluorosis. Sodium fluoride at 5, 10, 20 and 50 mg/kg body weight/day was injected subcutaneously for 100 days into 60 rabbits of both sexes. The control animals were given 1 cc distilled water/kg body weight/day for the same period. Biochemical studies showed hyperlipidemia, hyperphospholipidemia, and hypertriglyceridemia in the brain of treated animals of both sexes. The maximum increase in total lipids, phospholipids and triglycerides of brain occurred in animals treated with 50 mg NaF/kg. In male rabbits, the cholesterol content of brain rose suddenly (p<0.001) in the 5 mg fluoride group, followed by gradual decline in 10, 20 and 50 mg fluoride groups. In females, the cholesterol level rose (p<0.001) in animals of the 5, 10 and 20 mg fluoride groups and fell suddenly in the 50 mg fluoride group. Fluoride exerts an inhibitory effect on the free fatty acids in brain of both sexes. The relevance of these results in experimental fluorosis is discussed.
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Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus
Highlights Fluoride induced myelin damage in mouse hippocampus. Fluoride shortened the synaptic cleft and thickened the postsynaptic density. Fluoride altered the expressions of CREB, BDNF, and NCAM in hippocampus. To investigate the fluoride-induced neurotoxicity on mice hippocampus, healthy adult mice were exposed to 25, 50, and 100 mg NaF/L for 60 days.
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Brain mapping of mentally retarded children in high-fluoride regions
On the basis of routine EEG, this article used mapping technologies to conduct research on the brain electrical activities of mentally retarded children in high-fluoride regions. Results showed that the O energy percentages in the central, parietal, occipital, and left temporal areas of the mentally retarded group were significantly higher
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Fluoride and aluminium disturb neuronal morphology, transport functions, cholinesterase, lysosomal and cell cycle activities
Fluoride and aluminium have been reported to cause severe alterations in the brain. However, their exact mechanisms of neurotoxic activities remain unknown. AIM: This study was designed to investigate the role of fluoride and aluminium in neuronal transport, lysosomal, cell cycle protein and acetylcholinesterase activities. METHOD: Adult Wistar rats were given low
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[White matter injury of spinal cord in rats with chronic fluorosis and recovery after defluoriation.]
OBJECTIVE: To explore the injury mechanism for white matter of spinal cord and the improvement of function after defluoriation. METHODS: A total of 120 Wistar rats were separated randomly into 4 groups (n = 30 each). High [fluoride] group received high concentration NaF water (200 mg/L) to establish fluorosis model; control group
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ERK1/2-mediated disruption of BDNF–TrkB signaling causes synaptic impairment contributing to fluoride–induced developmental neurotoxicity
Highlights Rats were long–term chronic exposed to environmentally relevant doses of fluoride. Fluoride exposure results in synaptic alterations both in vivo and in vitro. Fluoride–induced cognitive failures correlates with synaptic deficits. BDNF–TrkB axis disruption contributes to fluoride–elicited impaired synaptogenesis. ERK1/2 plays a vital role in fluoride–induced BDNF–TrkB signaling disruption. Excessive
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are 78 studies reporting reduced IQ (75 studies with children and 3 studies with adults) and several on the impaired learning/memory in animals. And there are studies which link
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