Abstract
The neurotoxic effect of fluoride on lipid content of brain was assessed in rabbits during experimental fluorosis. Sodium fluoride at 5, 10, 20 and 50 mg/kg body weight/day was injected subcutaneously for 100 days into 60 rabbits of both sexes. The control animals were given 1 cc distilled water/kg body weight/day for the same period. Biochemical studies showed hyperlipidemia, hyperphospholipidemia, and hypertriglyceridemia in the brain of treated animals of both sexes. The maximum increase in total lipids, phospholipids and triglycerides of brain occurred in animals treated with 50 mg NaF/kg. In male rabbits, the cholesterol content of brain rose suddenly (p<0.001) in the 5 mg fluoride group, followed by gradual decline in 10, 20 and 50 mg fluoride groups. In females, the cholesterol level rose (p<0.001) in animals of the 5, 10 and 20 mg fluoride groups and fell suddenly in the 50 mg fluoride group. Fluoride exerts an inhibitory effect on the free fatty acids in brain of both sexes. The relevance of these results in experimental fluorosis is discussed.
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Fluoride exposure regulates the elongation phase of protein synthesis in cultured Bergmann glia cells.
Highlights Glia cells are target of fluoride toxicity. Fluoride decreases protein synthesis. Glial glutamate transport is increased by fluoride. Fluoride is an environmental pollutant present in dental products, food, pesticides and water. The latter, is the greatest source of exposure to this contaminant. Structural and functional damages to the central
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Changes in fluoride levels in the liver, kidney, and brain and in neurotransmitters of mice after subacute administration of fluoride
The effects of fluoride after subacute oral administration of NaF at levels of 0, 1, 5, 25, and 125 ppm F– were evaluated in adult male BALB/c mice. Fluoride levels in the murine liver, kidney, and cerebrum after one month were determined using a highly sensitive flow-injection apparatus with a
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Effects of fluoride on synaptic membrane fluidity and PSD-95 expression level in rat hippocampus.
The objective of this study is to investigate the neurotoxicity of drinking water fluorosis on rat hippocampus. Just weaning male Sprague-Dawley rats were randomly divided into four groups and given 15, 30, and 60 mg/L NaF solution and distilled water, respectively, for 9 months. The fluidity of brain synaptic membrane
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Neuroprotective effects of methyl-3-O-methyl gallate against sodium fluoride-induced oxidative stress in the brain of rats
Methyl-3-O-methyl gallate (M3OMG) is a rare natural product that showed promising in vitro antioxidant activities. In this study, the protective role of synthetic M3OMG against sodium fluoride (NaF)-induced oxidative stress in rat brain was evaluated. Animals were treated with either M3OMG (10 and 20 mg/kg i.p.), vitamin C (10 mg/kg
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Fluoride-induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats.
This study intended to determine the effects of various concentrations of fluoride (1, 10, 50 and 100 ppm) in drinking water for a period of 12 weeks on changes in haem biosynthesis pathway, oxidative stress and neurological variables supported by histopathological observations and fluoride in rats. The data indicates significant
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