Abstract
Adult Swiss Albino mice (6-7 weeks old) were treated with sodium fluoride (NaF) until autopsy. The organo-somatic index, histology and biochemistry of the intestines were observed at commencement of treatment and on the 7th, 15th and 30th day. The crypt cells exhibited cytoplasmic degranulation and vacuolation. Hydropic degeneration in lamina propria and muscular tissue, increase in the number of goblet cells, broken tips of villi, nuclear pyknosis, and abnormal mitoses were observed. The organo-somatic index decreased significantly on days 7 and 15. Total protein and cholesterol values declined significantly, whereas those of glycogen and acid, and alkaline phosphatase activities, increased significantly on day 7 to day 30. The results provide evidence of intestinal involvement in fluorosis.
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Toxic effects of chronic fluoride ingestion on the upper gastrointestinal tract
In a prospective case controlled study, we evaluated the adverse effects of long-term fluoride ingestion on the gastrointestinal tract. Ten patients with otosclerosis who were receiving sodium fluoride 30 mg/day for a period of 3-12 months, and 10 age- and sex-matched healthy volunteers were included. They were all evaluated clinically
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Environmental fluoride exposure disrupts the intestinal structure and gut microbial composition in ducks.
Highlights Intestinal structure and gut microbial composition and diversity depends on various animal and environment related factors. Fluoride and its compounds can accumulate in animals and plants and threaten public health through the food chain. Simple and electron microscopy coupled with 16S rRNA sequencing revealed that excessive fluoride exposure can
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Outbreak of acute fluoride poisoning caused by a fluoride overfeed, Mississippi, 1993.
OBJECTIVE: To determine the extent and confirm the cause of an August 1993 outbreak of acute fluoride poisoning in a small Mississippi community, thought to result from excess fluoride in the public water supply. METHODS: State health department investigators interviewed patrons of a restaurant where the outbreak first became manifest and
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Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.
Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary
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Gastric discomforts from fluoride in drinking water in Sanganer Tehsil, Rajasthan, India
A health survey of 1135 children and 1475 adults living in Sanganer Tehsil, Rajasthan, India, revealed a wide range of gastrointestinal (GI) discomforts associated with fluoride (F) in the groundwater in over 30 village areas. Complaints of abdominal pain including stomach ache, a bloated feeling, nausea, diarrhea, and constipation were
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Fluoride-Induced Gastric Symptoms in Human Clinical Trials
In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or
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Side Effects from Fluoride Gels: Gastric Distress
Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can
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Gastrointestinal Problems Among Individuals with Skeletal Fluorosis
Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article
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Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials
When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a
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Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach
The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The
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