Abstract
Adult Swiss Albino mice (6-7 weeks old) were treated with sodium fluoride (NaF) until autopsy. The organo-somatic index, histology and biochemistry of the intestines were observed at commencement of treatment and on the 7th, 15th and 30th day. The crypt cells exhibited cytoplasmic degranulation and vacuolation. Hydropic degeneration in lamina propria and muscular tissue, increase in the number of goblet cells, broken tips of villi, nuclear pyknosis, and abnormal mitoses were observed. The organo-somatic index decreased significantly on days 7 and 15. Total protein and cholesterol values declined significantly, whereas those of glycogen and acid, and alkaline phosphatase activities, increased significantly on day 7 to day 30. The results provide evidence of intestinal involvement in fluorosis.
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Suppressive effects of dietary high fluorine on the intestinal development in broilers
Fluoride (F) is a well-recognized hazardous substance. Ingested F initially acts locally on the intestines. The small intestine plays a critical role in the digestion, absorption, and defense. In this study, therefore, we investigated the effects of fluorine on the intestinal development by light microscopy, transmission electron microscopy, and histochemistry.
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Preventive effects of Lactobacillus johnsonii on the renal injury of mice induced by high fluoride exposure: Insights from colonic microbiota and co-occurrence network analysis.
Highlights L. johnsonii BS15 could protects the kidney tissue from renal lesion and dysfunction induced by high fluoride exposure. Colonic microbial structure and diversity was significantly altered by fluoride exposure and probiotic treatment. Fluoride- and probiotic-altered sensitive and well-connected species may be closely related to renal health. Fluoride (F) exposure
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Chronic treatment with fluoride affects the jejunum: insights from proteomics and enteric innervation analysis.
Gastrointestinal symptoms are the first signs of fluoride (F) toxicity. In the present study, the jejunum of rats chronically exposed to F was evaluated by proteomics, as well as by morphological analysis. Wistar rats received water containing 0, 10 or 50 mgF/L during 30 days. HuC/D, neuronal Nitric Oxide (nNOS),
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Fluoride for the treatment of postmenopausal osteoporotic fractures: a meta-analysis
We conducted an effectiveness meta-analysis to determine the efficacy of fluoride therapy on bone loss, vertebral and nonvertebral fractures and side effects in postmenopausal women. A literature search was conducted on MEDLINE, Current Contents and the Cochrane Controlled Trial Registry. Two independent reviewers selected randomized controlled trials which met predetermined
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Effects of acute fluoride exposure on the jejunum and ileum of rats: Insights from proteomic and enteric innervation analysis.
Highlights Water containing 25 mgF/Kg bw F provokes morphological changes and alters in several proteins in the jejunum and ileum; Organism might not have had time to adapt to its toxic effect. Therefore, the loss of energy may have not been repaired. Morphological changes in the gut, can be explained
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Side Effects from Fluoride Gels: Gastric Distress
Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can
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Fluoride-Induced Gastric Symptoms in Human Clinical Trials
In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or
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Gastrointestinal Problems Among Individuals with Skeletal Fluorosis
Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article
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Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials
When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a
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Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach
The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The
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