Abstract

Adult Swiss Albino mice (6-7 weeks old) were treated with sodium fluoride (NaF) until autopsy. The organo-somatic index, histology and biochemistry of the intestines were observed at commencement of treatment and on the 7th, 15th and 30th day. The crypt cells exhibited cytoplasmic degranulation and vacuolation. Hydropic degeneration in lamina propria and muscular tissue, increase in the number of goblet cells, broken tips of villi, nuclear pyknosis, and abnormal mitoses were observed. The organo-somatic index decreased significantly on days 7 and 15. Total protein and cholesterol values declined significantly, whereas those of glycogen and acid, and alkaline phosphatase activities, increased significantly on day 7 to day 30. The results provide evidence of intestinal involvement in fluorosis.

• Related Studies :

  • Controlling the fluoride dosage in a patient with compromised salivary function

    BACKGROUND:  High-concentration topical fluorides are used commonly to with compromised salivary function due to irradiation and chemotherapy. CASE DESCRIPTION:  The authors describe a 50-year-old man with previously treated cancer who was using tray-applied topical fluoride gel. He complained of gastric symptoms, difficulty in swallowing, leg muscle soreness and knee joint soreness.

  • Effect of sodium fluoride on gastric emptying and intestinal transit in mice

    Fluoride, a well-recognised harmful substance, is easily absorbed by the gastrointestinal mucosa. It is therefore conceivable that any alteration of the gastrointestinal motility can affect the rate of absorption of fluoride and leads to aggravation of its toxic effects. The effects of fluoride on gastric emptying and intestinal transit were

  • Revisiting Fluoride in the Twenty-First Century: Safety and Efficacy Considerations.

    Over 100 years of scientific literature is available which describes the long relationship between dentistry and the many possible applications of fluoride anion (F-) as successful therapeutic strategies. To date, systemic introduction of fluoride via water, milk and salt fluoridation, and fluoride-containing tablets, has been employed. Post-eruption topical fluoride products

  • Fluoride as a possible aetiological factor in non-ulcer dyspepsia

    A prospective case controlled study was conducted to evaluate the role of fluoride as a possible aetiological factor for non-ulcer dyspepsia (NUD). Twenty patients with NUD and 10 age and sex matched healthy controls were subjected to clinical evaluation, upper gastrointestinal endoscopy and biopsies from the gastric antrum and duodenum.

  • Exercise alleviated intestinal damage and microbial disturbances in mice exposed to fluoride.

    Highlights Exercise alleviated fluoride (F)-induced damage of intestinal morphology. Exercise inhibited the development of duodenal inflammation in fluoride-exposed mice. Exercise altered intestinal expression of tight junction in F-exposed mice. Exercise restored F-caused variations in gut microbiome composition and abundance. Gastrointestinal reaction is an important symptom of fluorosis and is associated

• Related FAN Content :

  • Fluoride-Induced Gastric Symptoms in Human Clinical Trials

    In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or

  • Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials

    When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a

  • Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach

    The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The

  • Side Effects from Fluoride Gels: Gastric Distress

    Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can

  • Gastrointestinal Problems Among Individuals with Skeletal Fluorosis

    Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article