Abstract
Toxic effects of the pyrethroid pesticide deltamethrin and water-borne fluoride, alone and in combination, on free radical mediated parameters are reported in rats. Twenty-four healthy adult Wistar rats of both sexes were divided into 4 groups with 6 rats in each group. Group I receiving no treatment served as the control. Group II and group III were orally administered deltamethrin (1/100 of LD50) and 20-ppm fluoride in their drinking water, respectively, for 28 days. An additional group IV was co-administered deltamethrin and fluoride at the same dosages as groups II and III. Enhanced oxidative stress was observed as shown by significantly increased lipid peroxidation and alterations in antioxidant parameters, especially in the fluoride- deltamethrin co-exposed group IV.
NOTE FROM FAN: Deltamethrin is a brominated pyrethroid insecticide. The specific foods that this pesticide is approved for in the U.S. are here.
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Effect of deltamethrin and fluoride co-exposure on the brain antioxidant status and cholinesterase activity in Wistar rats
The study evaluated the effect of commercial preparation of deltamethrin, Butox®, and fluoride (F-) co-exposure on the brain antioxidant status and cholinesterase activity in rats. Group A was untreated. Group B was gavaged Butox®, providing deltamethrin at the dose rate of 1.28?mg per kg body weight per day. Group C
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Interactive effect of arsenic and fluoride on cardio-respiratory disorders in male rats: possible role of reactive oxygen species.
Epidemiological evidence demonstrates positive correlation between environmental and occupational arsenic or fluoride exposure and risk to various cardio-respiratory disorders. Arsenic-exposure has been associated with atherosclerosis, hypertension, cerebrovascular diseases, ischemic heart disease, and peripheral vascular disorders, whereas Fluoride-exposure manifests cardiac irregularities and low blood pressure (BP). Present study aims to study
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Cardiovascular dysfunction and oxidative stress following human contamination by fluoride along with environmental xenobiotics (Cd & Pb) in the phosphate treatment area of Togo, West Africa.
Highlights The exposure of the population is important in relation to the routes of exposure levels of pollutants. Cd, Pb and F in human blood are high in subjects living in and around the phosphate processing plant. The variation of the biochemical indicators indicating the risk of cardiovascular diseases. The
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Free radical-induced nephrotoxicity following repeated oral exposure to chlorpyrifos alone and in conjunction with fluoride in rats
BACKGROUND/AIM: Chronic renal disorder is becoming a major health problem worldwide. The purpose of the present study was to investigate alterations in the renal antioxidant system in rats induced by repeated exposure to chlorpyrifos (CPF) alone and in conjunction with fluoride. MATERIALS AND METHODS: Wistar rats were randomly allocated to seven
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Antioxidant status in oral subchronic toxicity of fipronil and fluoride co-exposure in buffalo calves
The effects of fipronil and fluoride co-exposure were investigated on antioxidant status of buffalo calves. A total of 24 healthy male buffalo calves divided into 4 groups were treated for 98 consecutive days. Group I, receiving no treatment, served as the control. Animals of groups II and III were orally
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Fluoride content in tea and its relationship with tea quality.
J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected
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Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
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Dental Fluorosis & Enamel Hypoplasia in Children with Kidney Disease
Children with kidney disease are known to have high levels of fluoride in their blood and to be at risk for disfiguring tooth defects. Research suggests that high levels of fluoride in blood, which can cause the tooth defect known as dental fluorosis, can contribute to the defects that occur
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
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