Abstract
Fluoride by modifying the activity of mitochondrial enzymes may change their respiration rate. In this study NaF at concentrations 5, 10, and 50 µM had no effect on the State 3 respiration rate of rat cardiac mitochondria with succinate substrate. At a higher concentration of 7.5 mM, a significant (p<0.001) decrease by as much as 120.4 ± 5.7 nmol [O]/min/mg protein occurred in the State 3 respiration rate with succinate. Further increase in NaF concentration (15 and 25 mM) resulted in a reproducible decrease in the oxidation rate of the succinate in dose-dependent manner.
Excerpt:
… In summary, NaF at concentrations of 5, 10, and 50 µM had no effect on the State 3 respiration rate of mitochondria oxidizing succinate or pyruvate + malate. However, NaF concentrations of 7.5, 15, and 25 mM resulted in a reproducible decrease in the oxidation rate of the succinate in dose-dependent manner. Since topical application of F-containing dental products can lead to accumulation of F in the oral cavity, in some cases at fairly high concentrations (16), such procedures run the risk of possibly inhibiting mitochondrial function in cells of the oral cavity and may even be cardiotoxic as well.
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Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.
Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary
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The effects of the inhalation of hydrogen fluoride. I. The response following exposure to high concentrations.
The effects of inhalation exposure to hydrogen-fluoride (7664-39-3) (HF) were examined in New-Zealand-white-rabbits and guinea-pigs. Animals were exposed to HF in enclosed chambers at concentrations ranging from 8 to 0.024 milligrams per liter (mg/l) for 5 minutes to 41 hours. Mortality rates were recorded, general physical conditions were monitored, and
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Fluoride and calcium levels in the aorta
Among soft tissue organs which store fluoride (F-), the aorta contains the highest levels. [1-2]. Calcifications of arteries of the Monckeberg type have been reported in relatively young persons afflicted with skeletal fluorosis from endemic areas. [3-5] It was, therefore, of interest to determine whether or not there is a
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Effect of fluorine on heart arrhythmias in rats.
The antiarrhythmic activity of fluoride was studied in a model of CaCL2-induced heart arrhythmias in male albino rats. The prolonged intake of sodium fluoride with drinking water (2 mg/l for 1 month) significantly reduced the severity of arrhythmias that was evident as an increase in the latency and a decrease
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Observations on electrocardiograms in a population living in a region with coal-burning-borne endemic fluorosis after comprehensive controls
Objective: To observe the electrocardiogram (ECG) changes in the population living in the region with coal-burning-borne endemic fluorosis (EF for short) after comprehensive controls. Methods: People living in a region with coal-burning-borne EF in Bijie City of Guizhou Province were selected and then divided into 4 groups according to the
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