Tag: Mitochondria
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Effects of fluoride exposure on mitochondrial function: Energy metabolism, dynamics, biogenesis and mitophagy.
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Challenges of fluoride pollution in environment: Mechanisms and pathological significance of toxicity – A review.
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Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches.
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Increase of complex I and reduction of complex II mitochondrial activity are possible adaptive effects provoked by fluoride exposure.
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Protective role of maize purple plant pigment against oxidative stress in fluorosis rat brain.
Excerpts 1 Introduction Given the widespread presence of fluorine in the natural environment, individuals are exposed to fluoride via food intake, inhalation, and dermal contact. Drinking water represents the largest exposure source. In particular, in highly fluoridated regions and in some developed areas that fluoridate the public water supply to reduce dental caries, fluoride may […]
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Toxicity of fluoride on isolated rat liver mitochondria
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Fluoride-Induced Expression of Neuroinflammatory Markers and Neurophysiological Regulation in the Brain of Wistar Rat Model.
References Varner JA, Jensen KF, Horvath W, Isaacson RL (1998 Feb 16) Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Res 784(1–2):284–298. CAS Article Google Scholar Mahaboob Basha P, Saumya SM (2013 Apr) Suppression of mitochondrial oxidative phosphorylation and TCA enzymes in discrete brain regions […]
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Co-exposure to non-toxic levels of cadmium and fluoride induces hepatotoxicity in rats via triggering mitochondrial oxidative damage, apoptosis, and NF-kB pathways.
References Abarikwu SO, Njoku R-C, Lawrence CJ, Charles IA, Ikewuchi JC (2017) Rutin ameliorates oxidative stress and preserves hepatic and renal functions following exposure to cadmium and ethanol. Pharm Biol 55:2161–2169 CAS Article Google Scholar Abu-El-Zahab HS, Hamza RZ, Montaser MM, El-Mahdi MM, Al-Harthi WA (2019) Antioxidant, antiapoptotic, antigenotoxic, and hepatic ameliorative effects of L-carnitine […]
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Drp1/Mff signaling pathway is involved in fluoride-induced abnormal fission of hepatocyte mitochondria in mice.
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Fluoride induced mitochondrial impairment and PINK1-mediated mitophagy in Leydig cells of mice: In vivo and in vitro studies.