Studies on skeletal muscle biopsies in endemic skeletal fluorosis

Neurological manifestations of skeletal fluorosis have been attributed to compressive radiculomyelopathy. Experimental fluorosis has shown evidence of myopathic changes. Data on human muscle pathology is very scanty. This study included 22 patients with established osteofluorosis. 16 of them showed only EMG changes of neurogenic muscle disease. Histochemistry and histopathology of muscle biopsies showed

Health problems in fluoride endemic areas of Gaya District

Fluoride (F) was estimated in the groundwater of six blocks (Bodh Gaya, Manpur, Wazirganj, Belaganj, Amas, and Bankebazar) of Gaya District, Bihar, for different physio-chemical properties e.g. pH, total dissolved solids(TDS), conductivity, turbidity, total hardness (TH), calcium, magnesium, iron and fluoride. Morever 93 blood samples from different age groups including

New data for the validation of the mean daily maximum permissible concentration of hydrogen fluoride in atmospheric air

1.  Round-the-clock exposure to hydrogen fluoride concentrations of 0.10 and 0.03 mg/m3 causes inhibition in the central nervous system, decreases the activity of a number of enzymes, impairs the phosphorus-calcium metabolism, and causes the accumulation of fluorine in the body and damage to the internal organs and bone tissue. 2.  A

Fluorine Intoxication: A Clinical-Hygienic Study with a Review of the Literature and Some Experimental Investigations

The pathogenesis of endemic fluorosis: Research progress in the last 5 years.

Fluorine is one of the trace elements necessary for health. It has many physiological functions, and participates in normal metabolism. However, fluorine has paradoxical effects on the body. Many studies have shown that tissues and organs of humans and animals appear to suffer different degrees of damage after long-term direct

Skeletal Fluorosis: The Misdiagnosis Problem

It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.

Fluoride & Osteoarthritis

While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.

"Pre-Skeletal" Fluorosis

As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.

Skeletal Changes in Industrial and Endemic Fluorosis

Fluorotic changes in bones and joints were evaluated in 105 aluminum workers and 20 residents of an endemic fluorosis region in India.

Tea Intake Is a Risk Factor for Skeletal Fluorosis

A number of recent studies have found that heavy tea drinkers can develop skeletal fluorosis - a bone disease caused by excessive intake of fluoride.