Abstract not available
Apoptotic cell death following exposure to fluoride in rat alveolar macrophages.
Since inhaled fluoride is implicated in the acute respiratory failure, cytotoxic effects of fluoride on alveolar macrophages, primary target cells of inhaled toxicants, were investigated. The LC50 of sodium fluoride was estimated to be 0.41 mM, while 1 mM sodium chloride, bromide and iodide had virtually no effects on the
Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways
Fluoride is an environmental toxicant and induces dental fluorosis and oxidative stress. Lycopene (LYC) is an effective antioxidant that is reported to attenuate fluoride toxicity. To determine the effects of LYC on sodium fluoride (NaF) -induced teeth and ameloblasts toxicity, rats were treated with NaF (10 mg/kg) and/or LYC (10 mg/kg) by
The toxic effect of sodium fluoride on Spodoptera frugiperda 9 cells and differential protein analysis following NaF treatment of cells.
Highlights High concentrations of NaF changes Sf9 cell morphology. Cell viability decreased along with NaF concentration increased. Half-inhibitory concentration (IC50) for NaF of 5919 µM at 72 h. NaF induced cells apoptosis and dysregulation of protein expression. Accumulation of excess fluoride has a destructive effect on the environment, endangering human health,
Genes associated with sodium fluoride-induced human osteoblast apoptosis
This study aims to explore the potential pathways and molecular characteristics of fluorine-induced osteoblast apoptosis. In vitro fluorine-induced model was established with an osteogenesis sarcoma cell line Saos-2. Then flow cytometry was used to determine the mitochondrial membrane potential at 24 h after the intervention. 84 apoptosis-related genes in the
Effects of fluoride on cell cycle and apoptosis in cultured osteoblasts of rats.
To study the effects of fluoride on cell growth, cell cycle and apoptosis in cultured osteoblasts of rats. The enzymes digesting method was used to isolate the osteoblasts of rats. The activity of the cells was determined by the percents of reduced AlamarBlue. FCM was used to analyze cell cycle
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