Abstract
The aim of this study was to comp are the concentrations of fluoride (F) in cartilage, bone marrow, and synovial fluid taken from patients with osteoarthritis (OA). We also determined the correlation between OA risk factors, including age, sex, obesity, and hypertension, and F concentrations in the studied materials. The cartilage (n=27), bone marrow (n=29), and synovial fluid (n=22) were obtained from 29 patients (21 women and 8 men) with OA during knee replacement surgery. The median concentrations of F observed in studied materials could be arranged in the following descending order: cartilage > bone marrow > synovial fluid. The examination did not show a correlation between OA risk factors and F concentrations in the analyzed materials. Based on literature data and on the results of this study, we noticed that the level of F in the bone marrow and synovial fluid in patients with OA did not exceed 1.5 mg/L and 0.5 mg/L, respectively. The present study reports the first documentation of F concentrations in the synovial fluid and bone marrow of patients with OA.
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Fluoridation of public water supplies and its relation to musculoskeletal diseases
The fluoride content in parts per 1,000,000 of ash was estimated in 18 various bone samples from 14 patients with different forms of arthritis and from 1 patient who did not have arthritis, all of whom had ingested fluoridated water for a period ranging from three years and five months
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Industrial fluorosis [Franke et al.]
This is a review of findings on workers in an aluminum plant with industrial fluorosis. Early signs of the disease are nocturnal back pains and restriction of the rotation of the trunk. Stage I of the disease usually occurs after 10 years, stage II after 15 years and stage III
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Fluoride and strontium accumulation in bone does not correlate with osteoid tissue in dialysis patients
BACKGROUND: Osteomalacia is now a rare disease in dialysis patients in developed countries since the withdrawal of aluminium overload. The involvement of fluoride and strontium in the pathogenesis of the disease has been suggested. The aim of this study was to investigate a possible association between osteomalacia in dialysis patients
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The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue.
Bones are metabolically active organs. Their reconstruction is crucial for the proper functioning of the skeletal system during bone growth and remodeling, fracture healing, and maintaining calcium-phosphorus homeostasis. The bone metabolism and tissue properties are influenced by trace elements that may act either indirectly through the regulation of macromineral metabolism,
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Human vertebral bone: relation of strength, porosity, and mineralization to fluoride content
Radiographically normal vertebral bone cylinders from 80 male subjects were tested mechanicallly by static compression and analyzed for porosity, fluoride and ash content. As a group, they had low fluoride content, suggesting little prior intake, consonent with this geographic area. Nevertheless, increasing levels of fluoride were associated with bulkier bone,
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Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
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"Pre-Skeletal" Fluorosis
As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.
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Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
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