Abstract
The prevalence rates of Down’s syndrome at birth were compared for Massachusetts residents ingesting fluoridated and non-fluoridated water. The observations included nearly all children born alive with Down’s syndrome in Massachusetts during the 17-year period 1950-1966. A rate of 1.5 cases per 1000 births was found for fluoride-related births and appropriate comparison groups; the upper bound of a one-sided 95 per cent confidence interval for the ratio of fluoride to non-fluoride rates was 1.2. Thus, the data provide strong evidence that fluoridation does not cause any important elevation in risk for Down’s syndrome, at least not for several years after its introduction.
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Down syndrome, water fluoridation, and maternal age
It has been claimed that there is a positive association between the frequency of Down syndrome and the fluoridation of drinking water. It has also been suggested that this association is most pronounced in young women. Recent congenital malformations data obtained from birth certificates from large U.S. cities have been
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Water fluoridation and congenital malformations: no association
Data based on a total number of 1,387,027 births were used to compare the incidence of selected congenital malformations in fluoridated areas and that in areas where the water supply is deficient in fluoride. The incidence of selected congenital malformations in areas with fluoride supplementation of public water supplies was compared
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[New researches on mongolism related to the disease producing role of fluorine].
A new statistical study on the distribution of mongolism in cities in Illinois, United States, from January 1, 1950 to December 31, 1956, permits us to verify an increasing frequency of this affliction associated with the concentration of fluorine in the drinking water. This study follows a preceding inquiry on the
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Role des inhibiteurs enzymatiques dans l'etiologie du mongolisme
1) The low incidence of dental caries observed in mongoloid patients led to an investigation of the role of fluorine in this condition. 2) A statistical study of the geographical distribution of mongolism in Wisconsin, Illinois, Idaho, North and South Dakota (U.S.A.) shows a parallelism between the prevalence of this condition
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Editorial review: Fluoride and down's syndrome (mongolism)
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