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Effects of Fluorine on Neutrophil Extracellular Trap Formation through Regulating AMPK/p38 Signaling Pathway.
1. Introduction Fluoride is one of the essential microelements in the body. Long-term excessive intake of fluoride will cause systemic physiological and pathological changes [1]. Fluoride can not only damage bone organs but also accumulate in brain tissue through the blood-brain barrier, affecting the shape and function of brain nerve cells [2, 3]. In recent […]
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Exposure to environmental neurotoxic substances and neurodevelopment in children from Latin America and the Caribbean.
Introduction Environmental neurotoxicants are pollutants that can negatively affect many cellular metabolic-processes through different pathways: neuroendocrine/thyroid hormone disruption (Pb, methyl-Hg, organochlorines, and polychlorinated biphenyls-PCB), oxidative stress (Pb, methyl-Hg, organochlorines, and chlorpyrifos), dopamine dysfunction (Pb, methyl-Hg, As, chlorpyrifos, pyrethroids, and organochlorines) (Heyer and Meredith, 2017; Rock and Patisaul, 2018). Pistollato et al. (2020) studied neurotoxic substances […]
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Lithium-ion Battery Recycling: Studies/Reports on alternatives to the use of incineration.
Note: This series concerns a proposal to use incineration to recycle lithium-ion batteries. It was proposed for Endicott in Broome County NY. The proposal resulted in the formation of the group NoBurnBroome on April 15, 2020, to oppose the proposal, which it successfully accomplished in February 2021. The Fluoride Action Network was interested in this […]
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Human studies on Fluoride’s Neurotoxicity
U.S. agencies funding the studies: NIH (National Institute of Heath). The NIEHS and the NIDCR come under the aegis of the NIH. NIEHS (National Institute of Environmental Health Sciences) has responsibility for the NTP (National Toxicology Program). The NIEHS is the research arm of U.S. regulatory agencies. The NTP is best known for its Reports […]
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Neurobehavioural effects of developmental toxicity
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Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies.
Fluoride exposure from the Odense Child Cohort (OCC) While the addition of fluoride to drinking water is not legal in Denmark, elevated fluoride concentrations up to 1.5 mg/l naturally occur in groundwater in parts of the country,13 and some types of tea, especially black tea, constitute an additional source of exposure.14 In Odense municipality, the […]
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Slightly Elevated Serum Ionic Fluoride Levels Inhibit Insulin Secretion and Increase Glucose Levels in a General Japanese Population: a Cross-sectional Study.
References 1. Whitford GM (1996) The metabolism and toxicity of fluoride. Monogr Oral Sci 16. Rev 2. 1–153 2. Tsunoda N, Sakurai S, Tsunoda H (1986) Gastrointestinal absorption of fluoride in humans—a comparative study of NaF and CaF2. In: Humio T and Ming-Ho Yu (ed) Fluoride research 1985, studies in environmental science 27. Elsevier, Amsterdam, […]
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Fluorosis and osteomalacia
Clinical history A 30-year-old taxicab driver presented with a 1-year history of low back pain radiating into the posterior aspect of both legs, stiffness during inactivity, and proximal upper and lower limb myalgia. Symptoms were poorly controlled with acetaminophen. The medical history was unremarkable. The patient was a vegetarian, smoked 5 cigarettes per day, and […]
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MRI features of spinal fluorosis: results of an endemic community screening
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The effects of excessive fluoride intake
The number of persons with markedly worn teeth does not appear to be directly related to the fluoride content of the water consumed. There is a suggestion, however, that the wearing down process starts earlier in places with exceptionally high levels of fluoride in the water. The teeth most commonly affected were the central incisors. […]