Fluoride (F) is a toxic and reactive element, and exposure to it passes almost unnoticed, with the consumption of tea, fish, meat, fruits, etcetera and articles of common use such as: toothpaste additives; dental gels, non-stick pans and razor blades as Teflon. It has also been used with the intention of reducing the dental cares.
Fluoride can accumulate in the body, and it has been shown that continuous exposure to it causes damaging effects on body tissues, particularly the nervous system directly without any previous physical malformations.
Several clinical and experimental studies have reported that the F induces changes in cerebral morphology and biochemistry that affect the neurological development of individuals as well as cognitive processes, such as learning and memory. F can be toxic by ingesting one part per million (ppm), and the effects they are not immediate, as they can take 20 years or more to become evident.
The prolonged ingestion of F may cause significant damage to health and particularly to the nervous system. Therefore, it is important to be aware of this serious problem and avoid the use of toothpaste and items that contain F, particularly in children as they are more susceptible to the toxic effects of F.
Fluoride Developmental Neurotoxicity- Overview of Evidence and Evaluation of Risk at Exposures Due to Artificial Fluoridation.
The topic of fluoride developmental neurotoxicity has received great attention recently due to the publication of several high-profile studies and because of the questions these raise about the safety of water fluoridation, a long-established public health measure to reduce tooth decay. The recent studies have found associations between fluoride exposures
Acetylcholinesterase activity in fluorosis adversely affects mental well-being: an experimental study in rural Rajasthan
Fluoride toxicity is a burgeoning problem worldwide and also in Rajasthan in India. In the state of Rajasthan, almost all districts have high fluoride (up to 18.0 ppm) in their drinking/ground water sources and about 11 million of the population [is] at risk. Several clinical and experimental studies have reported
Psychological studies of human performance as affected by traces of enflurane and nitrous oxide.
Thirty human subjects were exposed for four hours to 500 ppm N-2O and 15 ppm enflurane in air and then, within five minutes, given a 35-minute battery of psychological tests. Performance of a divided-attention audiovisual task and a digit-span memory test were significantly decreased compared with control data following exposure
Rat developmental fluoride exposure affects retention memory, leads to a depressive-like behavior, and induces biochemical changes in offspring rat brains.
Water is the principal source of human exposure to fluoride (F). The high permeability of the placenta and blood-brain barrier to F during the intrauterine life up to the end of lactation may be crucial to neurological fetus development. Therefore, this study explores the effects of 5 and 10 mg/l F exposure
Effects of drinking water fluorosis on L-type calcium channel of hippocampal neurons in mice.
Highlights Fluoride affects calcium metabolism in mice. Fluoride significantly increases the current peak of the LTCCs. Fluoride reduces the activation voltage of LTCCs. Fluoride delays the inactivation or deactivation of LTCCs. The study aimed to investigate the effects of drinking water fluorosis on L-type calcium channels (LTCCs) in mouse hippocampal neurons.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
Fluoride & IQ: 76 Studies
• As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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