Excerpt:

In conclusion, exposure to high fluoride levels [30 & 100 ppm] in drinking water during early stages of life led to increased oxidative stress in the liver of rats as indicated by elevated MDA level and disturbed antioxidant defenses. Adaptive mechanisms in the form of increased activities of GSH-Px and GST operated to combat fluoride induced oxidative stress. But, increased oxidative stress led to depletion of the intrinsic free radical scavengers glutathione and ascorbic acid.

Print PDF

• Related Studies :

  • Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat

    BACKGROUND: Sodium fluoride (NaF) intoxication is associated with oxidative stress and altered antioxidant defense mechanism. The present study was carried out to evaluate the potential protective role of blackberry and quercetin (Q) against NaF-induced oxidative stress and histological changes in liver, kidney, testis and brain tissues of rats. METHODS: The rats

  • Epigallocatechin gallate effectively ameliorates fluoride-induced oxidative stress and DNA damage in the liver of rats

    RETRACTION MADE IN MARCH 2020: The Editors-in-Chief of the Canadian Journal of Physiology and Pharmacology were alerted to cases of image manipulation in the article entitled “Epigallocatechin gallate effectively ameliorates fluoride-induced oxidative stress and DNA damage in the liver of rats” (see http://dx.doi.org/10.1139/cjpp-2012-0347). Thus, the Editors-in-Chief have retracted the paper from

  • Sesamin attenuates histological alterations, oxidative stress and expressions of immune-related genes in liver of zebrafish (Danio rerio) exposed to fluoride.

    Highlights Sesamin alleviated histological damage and oxidative stress in liver. Sesamin remarkably inhibited the inflammatory reaction in fluoride-exposed liver. Sesamin reversed activities of immune-related enzymes in fluoride-exposed liver. Sesamin reversed expressions of immune-related mRNAs liver exposed to fluoride. Sesamin could protect liver against fluoride-induced damage. Sesamin is the main lignan in

  • Induction of oxidative stress and related transcriptional effects of sodium fluoride in female zebrafish liver

    The effects of sodium fluoride (NaF) exposure on the induction of oxidative stress and alteration of gene expressions were studied in the liver of female zebrafish (Danio rerio). Zebrafish, exposed to 15 ppm NaF for 30 and 90 days, exhibited liver histopathology including hyperplassia, cytoplasmic degeneration and nuclear fragmentation. Antioxidant enzyme (GST,

  • Evaluation of serum lipoprotein and tissue antioxidant levels in sheep with fluorosis

    The aim of this study was to evaluate serum lipoprotein and tissue antioxidant levels of sheep with and without fluorosis living in a volcanic area of Turkey. Fifteen Akkaraman sheep with fluorosis in the A?ri region north of Lake Van and 10 Akkaraman sheep without fluorosis in the Van region

• Related FAN Content :

  • Fluoride content in tea and its relationship with tea quality.

    J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected

  • Nutrient Deficiencies Enhance Fluoride Toxicity

    It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,

  • Fluoride & Oxidative Stress

    A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. It is also well established that fluoride's toxic effects can be ameliorated by exposure