Abstract
OBJECTIVE: To investigate the pathogenesis of brain damage by fluoride intoxication, phospholipid content, and fatty acid composition in rat brain with fluorosis were annlysed.
METHODS: Wistar rats were fed with NaF in various amounts and time periods to produce the animal model with chronic fluorosis. Phospholipid content and fatty acids composition were analysed using high performance liquid chromatography and gas chromatography, respectively.
RESULTS: All animals fed with high amount of fluoride suffered from chronic fluorosis. The total brain phospholipid content was lower in the rat treated with fluoride, which mainly influenced phosphatidylethanolamine, phosphatidylcholin, and phosphatidylserine. No modifications were detected in fatty acid and aldehyde compositions of individual phospholipid classes.
CONCLUSION: The metabolism of brain phospholipid might be interfered by fluoride accumulated in brain tissue, which is related with the degeneration of neuron. The changes of brain phospholipid could be involved in the pathogenesis of chronic fluorosis.
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The relationship between the fluoride levels in drinking water and the schooling performance of children in rural areas of Khartoum State, Sudan
Geogenic fluoride ion (F) contamination of groundwater has drawn worldwide attention due to its considerable impact on human health. In this study, the relationships between groundwater F levels, collected in the rainy and dry seasons from 16 rural areas in Khartoum state, Sudan, and the schooling performances of 775 primary
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A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.
This article is a preprint and has not been peer-reviewed. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. Abstract As a safe exposure level for fluoride in pregnancy has not been established, we used data from two prospective studies
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Neuroprotective effect of ascorbic acid and ginkgo biloba against fluoride caused neurotoxicity
Excessive consumption of fluoride through drinking water or other sources lead to skeletal and dental fluorosis. According to the world health organization 23 nations are facing the problem of fluorosis. In the recent past researchers describe the non-skeletal fluorosis where soft tissues and major organs are the victims of fluoride
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Perinatal exposure to sodium fluoride with emphasis on territorial aggression, sexual behaviour and fertility in male rats.
Territorial aggression, sexual behaviour and fertility parameters were evaluated at adulthood of male rats previously exposed to different concentrations of sodium fluoride (Na-F) at their gestation, lactation and postweaning period till maturation. Sixty weanling male Wistar rats were received Na-F via their dams from second trimester of their pregnancy onward
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Dose-response analyses of the 27 human developmental neurotoxicity studies ranked highest quality by National Toxicology Program (NTP) systematic review.
BACKGROUND AND AIM: The National Toxicology Program (NTP) has been conducting a systematic review of the evidence for fluoride’s neurotoxicity. Drafts of the NTP report conclude fluoride is a presumed hazard for developmental neurotoxicity, but have not included rigorous dose-response analyses to estimate a safe dose. This is of great
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Fluoride & IQ: 74 Studies
• As of May 2022, a total of 83 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 74 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure to
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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