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[Effect of excessive fluoride intake on mental work capacity of children and a preliminary study of its mechanism]
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Hua Xi Yi Ke Da Xue Xue Bao (Journal of West China University of Medical Sciences)
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Li Y, Li X, Wei S.
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25(2):188-91.
Abstract
We made an investigation in 157 children, aged 12-13, born and grew up in a coal burning pattern endemic fluorosis area and an experiment on excessive fluoride intake in rat. The results showed:
(1) Excessive fluoride intake since early childhood would reduce mental work capacity (MWC) and hair zinc content:
(2) The effect on zinc metabolism was a mechanism of influence on MWC by excessive fluoride intake;
(3) Excessive fluoride intake decreased 5-hydroxy indole acetic acid and increased norepinephrine in rat brain; whether this is also a mechanism of the influence on MWC awaits confirmation.