Sunday, December 12th, 2021

Fluoride Alters Signaling Pathways Associated with the Initiation of Dentin Mineralization in Enamel Fluorosis Susceptible Mice.

References 1. Fejerskov O, Larsen MJ, Josephsen K, Thylstrup A (1979) Effect of long-term administration of fluoride on plasma fluoride and calcium in relation to forming enamel and dentin in rats. Scand J Dent Res 87(2):98–104 CAS  PubMed  Google Scholar 2. Vieira A, Hancock R, Dumitriu M, Schwartz M, Limeback H, Grynpas M (2005) How […]

Saturday, November 20th, 2021

Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis.

1. Introduction Fluorine is one of the most common halogens, which usually exists in the environment as compounds. Fluorine or fluoride enters the human body primarily through drinking water, food, and air. Once absorbed into the bloodstream, it is easily transported throughout the body in the form of ions. More than 90% of absorbed fluoride […]

Monday, July 12th, 2021

Preliminary screening of fluorine-stained osteoblastic apoptosis-related microRNA.

Sunday, April 4th, 2021

The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue.

5. Fluorine (F) According to some researchers, fluorine is a microelement needed for proper development. However, in the case of this element, it is important to determine its concentration in the human body, because the difference between the tolerated dose and the toxic dose is very small [110]. Fluorides (F-), the ionic form of fluorine, […]

Saturday, November 16th, 2019

Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification.

Highlights Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride inhibits Ihh/PTHrP feedback loop during endochondral ossification. Abstract Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride […]

Sunday, August 25th, 2019

Influence of calcium supplementation against fluoride-mediated osteoblasts impairment in vitro: Involvement of canonical Wnt/B-catenin signaling pathway.

Friday, March 29th, 2019

[Biological exposure limits caused by co exposure to fluoride and arsenic based on Wnt signaling pathway].

Sunday, August 12th, 2018

Fluoride Induces Neuroinflammation and Alters Wnt Signaling Pathway in BV2 Microglial Cells.

Fluoride exposure increases IL-1B and TNF-a production and changes the cellular oxidation and antioxidation status [5, 19]. Neuroinflammation seems to be an important mediator of the effects of fluoride. Neuroinflammation, which is mediated by microglia, contributes to most pathological neurologic processes, including CNS infections, ischemic stroke, neurodegenerative disease, and anesthetic neurotoxicity. Increased pro-inflammatory mediator production […]

Sunday, March 9th, 2014

Fluoride promotes osteoblastic differentiation through canonical Wnt/B-catenin signaling pathway

Sunday, February 16th, 2014

Suppression of Sclerostin and Dickkopf-1 levels in patients with fluorine bone injury