Tag: WNT signaling
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MicroRNAs in fluorosis pathogenesis: impact on dental, skeletal, and soft tissues.
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Fluoride Alters Signaling Pathways Associated with the Initiation of Dentin Mineralization in Enamel Fluorosis Susceptible Mice.
References 1. Fejerskov O, Larsen MJ, Josephsen K, Thylstrup A (1979) Effect of long-term administration of fluoride on plasma fluoride and calcium in relation to forming enamel and dentin in rats. Scand J Dent Res 87(2):98–104 CAS PubMed Google Scholar 2. Vieira A, Hancock R, Dumitriu M, Schwartz M, Limeback H, Grynpas M (2005) How […]
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Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis.
1. Introduction Fluorine is one of the most common halogens, which usually exists in the environment as compounds. Fluorine or fluoride enters the human body primarily through drinking water, food, and air. Once absorbed into the bloodstream, it is easily transported throughout the body in the form of ions. More than 90% of absorbed fluoride […]
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Preliminary screening of fluorine-stained osteoblastic apoptosis-related microRNA.
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The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue.
5. Fluorine (F) According to some researchers, fluorine is a microelement needed for proper development. However, in the case of this element, it is important to determine its concentration in the human body, because the difference between the tolerated dose and the toxic dose is very small [110]. Fluorides (F-), the ionic form of fluorine, […]
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Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification.
Highlights Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride inhibits Ihh/PTHrP feedback loop during endochondral ossification. Abstract Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride […]
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Influence of calcium supplementation against fluoride-mediated osteoblasts impairment in vitro: Involvement of canonical Wnt/B-catenin signaling pathway.
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[Biological exposure limits caused by co exposure to fluoride and arsenic based on Wnt signaling pathway].
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Fluoride Induces Neuroinflammation and Alters Wnt Signaling Pathway in BV2 Microglial Cells.
Fluoride exposure increases IL-1B and TNF-a production and changes the cellular oxidation and antioxidation status [5, 19]. Neuroinflammation seems to be an important mediator of the effects of fluoride. Neuroinflammation, which is mediated by microglia, contributes to most pathological neurologic processes, including CNS infections, ischemic stroke, neurodegenerative disease, and anesthetic neurotoxicity. Increased pro-inflammatory mediator production […]
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Fluoride promotes osteoblastic differentiation through canonical Wnt/B-catenin signaling pathway