Fluoride is a common element in nature and our daily life, and excessive intake of this element can cause fluorosis and irreversible brain damage. The toxic effects of fluoride on the central nervous system may be attributed to the release of inflammatory cytokines and ROS. GSK3B is a key protein that modulates NF-kB activity and inflammatory cytokine levels and plays an important role in the Wnt signaling pathway. In this study, we found that fluoride altered the inflammatory status and oxidative stress by inhibiting Wnt signaling pathway activity. This study thus provides a valid basis for the fluorine-induced neuroinflammation injury theory.
*Original abstract online at https://link.springer.com/article/10.1007/s10753-017-0556-y
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This study was supported by BK20151159 from the Natural Science Foundation of Jiangsu Province, China, Project 81501185 of National Natural Science Foundation of China, Jiangsu Provincial Medical Youth Talent No.QNRC2016369, Xuzhou Medical Talents Project and Xuzhou technological and scientific project No. KC14SH050.