Abstract
Due to many advantages Caenorhabditis elegans (C. elegans) has become a preferred model of choice in many fields, including neurodevelopmental toxicity studies. This review discusses the benefits of using C. elegans as an alternative to mammalian systems and gives examples of the uses of the nematode in evaluating the effects of major known neurodevelopmental toxins, including manganese, mercury, lead, fluoride, arsenic and organophosphorus pesticides. Reviewed data indicates numerous similarities with mammals in response to these toxins. Thus, C. elegans studies have the potential to predict possible effects of developmental neurotoxicants in higher animals, and may be used to identify new molecular pathways behind neurodevelopmental disruptions, as well as new toxicants.
*Free full-text study online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520156/
-
-
Protective effects of aqueous extract of fruit pulp of Tamarindus indica on motor activity and metabolism of the gastrocnemius muscle of rats treated with fluoride
This study reports the protective effects of tamarind ingestion against fluoride induced changes on motor activity and metabolism of Gastrocnemius muscle (GM) of rats. The male Wistar rats were divided into four groups - control, fluoride treated i.p. (20 mg NaF/Kg bw) and Tamarind (Tamarindus indicus III -150mg/kg bw and
-
Study of cognitive function impairment caused by chronic fluorosis.
Objective: To investigate whether an impairment in cognitive function exists in patients diagnosed with fluoride poisoning as well as its biological basis. Methods: Individuals suffering from fluoride poisoning from a high fluorine region were selected for the study group, while healthy individuals from a nonendemic region were selected as the control group. Using
-
Effects of chronic fluorosis on CAMKIIA, C-FOS, BAX, and BCL-2 channel signalling in the hippocampus of rats
In this study, the neurotoxicity of fluoride (F) in the hippocampus of rats exposed to 15, 30, and 60 mg NaF/L in their drinking water for nine months was investigated. Compared with the control (<0.5 mg F/L), significant increases in the expression of calcium/calmodulin-dependent kinase II alpha (CaMKII?) (F=5.228, p<0.05)
-
Assessment of Fluoride Content in Water and Its Impact on the Intelligence Quotient of School Children Aged 12–13 Years.
Background: The preliminary study was undertaken with the aim to assess the effect of fluoride content in water on the Intelligence Quotient (IQ) of school children aged 12-13 years residing in areas that differ with respect to fluoride levels. Materials and Methods: The IQ was measured using Raven’s Colored Progressive Matrices
-
Effect of fluoride exposure on the intelligence of school children in Madhya Pradesh, India.
Objective: To assess the relationship between exposure to different drinking water fluoride levels and children's intelligence in Madhya Pradesh state, India. Materials and Methods: This cross-sectional study was conducted among 12-year-old school children of Madhya Pradesh state, India. The children were selected from low (< 1.5 parts per million) and high
Related Studies :
-
-
-
Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are 78 studies reporting reduced IQ (75 studies with children and 3 studies with adults) and several on the impaired learning/memory in animals. And there are studies which link
-
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
-
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
-
Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
-
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
Related FAN Content :
-