Abstract

Oral administration of sodium fluoride (NaF, 6 and 12 mg/kg body weight/day) to Swiss strain male albino mice for 30 days caused significant dose-dependant reduction in the content of acidic, basic, neutral, and total protein in cerebral hemisphere, cerebellum and medulla oblongata region of brain. After 30 days of NaF treatment, followed by withdrawal of treatment for 30 days, partial but significant amelioration occurred. Administration of 2% black tea extract alone for 30 days did not cause any significant effect. However, concurrent administration of NaF and black tea extract for 30 days caused significant amelioration in all parameters studied.

• Related Studies :

  • Mitigation of sodium fluoride induced toxicity in mice brain by black tea infusion.

    SUMMARY: In an extension of previous work on fluoride (F) toxicity in a group of 80 Swiss albino mice, the mitigating effects of polyphenols in black tea on the F-induced increase in glycogen, cholesterol, and total lipids in the cerebral hemisphere (CH), cerebellum (CB), and medulla oblongata (MO) regions of

  • Black tea extract mitigation of NaF-induced lipid peroxidation in different regions of mice brains.

    SUMMARY: As part of our investigation of fluoride toxicity effects in a group of 80 Swiss albino adult male mice, we examined the mitigating effects of black tea extract (BTE) on the F-induced enzymatic and non-enzymatic parameters of oxidative stress in the cerebral hemisphere (CH), cerebellum (CB), and medulla oblongata (MO) of the

  • Fluoride intake from the consumption of refreshment drinks and natural juices.

    Highlights Soft-drinks and juices (65) were analyzed by potentiometry. Tea-based beverages had the highest fluoride content. Fluoride intake does not lead to a risk in adult health. Consumption of these beverages by children should be moderated. Fluoride plays an important role in the prevention of dental decay and in the reduction

  • Distribution and Removal of Fluoride Ions in the Drinking Waters in the Algerian South (Ouargla as a Showcase)

    In certain countries, the Algerian South in particular, where the scarcity of drinking water resources of good quality has constrained the local populations to consume the underground waters that are rich in fluoride. Fluoride constitutes an essential component for the human body in moderate rates, between 0.5 to 1.5 mg/l of

  • Combination of fluoride and endosulfan induced teratogenicity and developmental toxicity in Swiss albino mice exposed during organogenesis.

    The present investigation was conducted to evaluate the teratogenic and developmental toxicity of fluoride and endosulfan alone and in combination in pregnant Swiss albino mice exposed during the organogenetic period (5-14 days) of gestation. Fluoride (25.1 mg/kg body weight in water) and endosulfan (1.8 mg/kg bw by oral intubation) when

• Related FAN Content :

  • Estimated "Threshold" Doses for Skeletal Fluorosis

    For over 40 years health authorities stated that in order to develop crippling skeletal fluorosis, one would need to ingest between 20 and 80 mg of fluoride per day for at least 10 or 20 years. This belief, however, which played an instrumental role in shaping current fluoride policies, is now acknowledged by the National Academy of Sciences (NAS) and other US health authorities to be incorrect.

  • Exposure Pathways Linked to Skeletal Fluorosis

    Excessive fluoride exposure from any source -- and from all sources combined -- can cause skeletal fluorosis. Some exposure pathways , however, have been specifically identified as placing individuals at risk of skeletal fluorosis. These exposure pathways include: Fluoridated Water for Kidney Patients Excessive Tea Consumption High-Fluoride Well Water Industrial Fluoride Exposure Fluorinated Pharmaceuticals (Voriconazole

  • The Lancet: Fluoride Studies in a Patient with Arthritis

    It is possible that fluoride intake from tea may be sufficient to cause fluorosis, and I report here a case which gives some evidence for this.

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

  • Fluoride content in tea and its relationship with tea quality.

    J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected