SUMMARY: As part of our investigation of fluoride toxicity effects in a group of 80
Swiss albino adult male mice, we examined the mitigating effects of black tea extract
(BTE) on the F-induced enzymatic and non-enzymatic parameters of oxidative stress
in the cerebral hemisphere (CH), cerebellum (CB), and medulla oblongata (MO) of the brains of these mice. Oral administration of 6 and 12 mg NaF/kg bw/day to the mice for 30 days resulted in a significant increase in level of lipid peroxidation (LPO) and dehydroascorbic (DAA) acid as well as a decrease in glutathione (GSH), total
ascorbic acid (TAA), and reduced ascorbic acid. In addition, the activities of the
enzymatic antioxidants catalase (CAT), superoxide dismutase (SOD), glutathione
reductase (GSH-Pr), and glutathione peroxidase (GSH-Px) as well as cholinesterase
(ChE) also decreased. No significant recovery in any of these parameters was
observed upon withdrawal of the NaF treatment for 30 days. However, administration of BTE along with the NaF during the experiment resulted in significant mitigation of all the NaF-induced effects that were examined.
Mitigation of sodium fluoride induced toxicity in mice brain by black tea infusion.
SUMMARY: In an extension of previous work on fluoride (F) toxicity in a group of 80 Swiss albino mice, the mitigating effects of polyphenols in black tea on the F-induced increase in glycogen, cholesterol, and total lipids in the cerebral hemisphere (CH), cerebellum (CB), and medulla oblongata (MO) regions of
Public-health risks from tea drinking: Fluoride exposure.
Aims: Due to new evidence on fluoride neurotoxicity during early life, this study examined maternal exposure to fluoride through tea consumption in a low-fluoride region and measured fluoride releases from commercially available teas (tea bags and loose teas) to determine the need to limit fluoride exposure. Methods:
Amelioration by black tea of sodium fluoride-induced changes in protein content of cerebral hemisphere, cerebellum and medulla oblongata in brain region of mice.
Oral administration of sodium fluoride (NaF, 6 and 12 mg/kg body weight/day) to Swiss strain male albino mice for 30 days caused significant dose-dependant reduction in the content of acidic, basic, neutral, and total protein in cerebral hemisphere, cerebellum and medulla oblongata region of brain. After 30 days of NaF
Prenatal and postnatal ingestion of fluorides: fourteen years of investigation -- final report
Three different sources of fluoride were used in this study. The tablets containing 1.0 mgm fluorine ion from CaF2; 1.2 mgm fluorine ion, from NaF and 0.825 mgm fluorine ion from Na2PO3F, each. These values were chosen so that each tablet would contain approximately the same amount of the ion
T for target organ, timing, and fluoride exposure.
Background: The brain is a main target organ for fluoride toxicity during early development. Based on recent epidemiological evidence, an approximate benchmark dose has been calculated for pregnant women at about 0.2 mg/L in water (or urine). This means that current limits for water-fluoride are too high, but tea has
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Fluoride Content of Tea
Tea, particularly tea drinks made with lower quality older leaves, contain high levels of fluoride. Because of these high levels, research has found that individuals who drink large amounts of tea can develop skeletal fluorosis -- a painful bone disease caused by excessive fluoride intake. Since skeletal fluorosis is often misdiagnosed by
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
Fluoride & IQ: 68 Studies
As of February 2021, a total of 76 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 68 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
The Lancet: Fluoride Studies in a Patient with Arthritis
It is possible that fluoride intake from tea may be sufficient to cause fluorosis, and I report here a case which gives some evidence for this.
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