Tag: Vacuolation
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Neurotoxicity induced by fluoride in rat cerebral cortex
In cerebral cortex of the rats, treated with 100 ppm of sodium fluoride, there was disorganization of granular cell layer. The granule cells were accumulated in the form of clumps. Some pyramidal neurons showed chromatolysis (Fig. 2) and were shrunken with vacuolation around them (Fig. 4). The nuclei of some pyramidal neurons were eccentric in […]
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The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission
In conclusion, the effects of NaF on a cell’s survival and integrity suggested that different concentrations NaF had direct toxic effects on the Neuro-2A cell line. NaF not only reduced the expression of select axonal proteins, but also prevented the secretion and delivery of the neurotransmitter glutamate.We found that expression of glutamate and its receptor, […]
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Effect of fluoride on brain of albino-rabbit – An experimental study.
From Table 1: Gross and brain cyto-architecture changes of experimental animals at the end of 16 weeks. Changes in Brain Cytoarchitecture: The neurones lost their angular or pyramidal shape and acquired a plump, ovoid, rounded, or characteristic “ballooned” appearance (Figure 1). The nucleus was displaced to the periphery or axonal base and was shrunken, pyknotic, […]
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Cerebral neurodegeneration in experimental fluorosis
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Dental fluorosis and catalase Immunoreactivity of the Brain Tissues in rats exposed to high fluoride pre- and postnatally
At 3 months in the cerebellum, most of the neurons had normal cell structures and only a few Purkinje cell irregularities were notable, such as cell swelling and balloon-like cells in rats subjected to 30 ppm fluoride. In the cerebrum and hippocampus, no neuronal damage was observed in rats exposed to 30 ppm fluoride. However, […]
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Histopathological investigation of fluoride-induced neurotoxicity in rabbits
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Symposium on the non-skeletal phase of chronic fluorosis: The spinal cord
The author presents evidence of damage to the spinal cord in skeletal fluorosis. Since pressure on the cord by osteophytes was ruled out, direct action of fluoride on cord tissue is likely to be responsible for this condition. Neurological complications of skeletal fluorosis have been described in endemic areas, especially in lndia. They consist of […]
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Fluoride-induced brain damages in suckling mice
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Fluoride toxicity and status of serum thyroid hormones, brain histopathology, and learning memory in rats: a multigenerational assessment.