Abstract
INTRODUCTION:
Fluoride (F) is a toxic and reactive element, and exposure to it passes almost unnoticed, with the consumption of tea, fish, meat, fruits, etcetera and articles of common use such as: toothpaste additives; dental gels, non-stick pans and razor blades as Teflon. It has also been used with the intention of reducing the dental cares.
DEVELOPMENT:
Fluoride can accumulate in the body, and it has been shown that continuous exposure to it causes damaging effects on body tissues, particularly the nervous system directly without any previous physical malformations.
BACKGROUND:
Several clinical and experimental studies have reported that the F induces changes in cerebral morphology and biochemistry that affect the neurological development of individuals as well as cognitive processes, such as learning and memory. F can be toxic by ingesting one part per million (ppm), and the effects they are not immediate, as they can take 20 years or more to become evident.
CONCLUSION:
The prolonged ingestion of F may cause significant damage to health and particularly to the nervous system. Therefore, it is important to be aware of this serious problem and avoid the use of toothpaste and items that contain F, particularly in children as they are more susceptible to the toxic effects of F.
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Cognitive impairment and risk factors in elderly people living in fluorosis areas in China
Residents living in fluorosis areas generally experienced long-term exposure to excessive fluoride in drinking water. The adverse effects of high fluoride levels on the nervous system have been studied; however, the effect of fluoride exposure on cognitive functions of elderly people in fluorosis areas is rarely reported. This study was
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Neurobehavioral evaluation of soil and structural fumigators using methyl bromide and sulfuryl fluoride.
Neurobehavioral functions affected by methyl bromide exposure were evaluated in California structural and soil fumigators using methyl bromide and sulfuryl fluoride. Sampling data revealed that structural fumigators are exposed for up to 1.5 hrs/day to 0-2.2 ppm methyl bromide and/or 10-200 ppm sulfuryl fluoride, and soil fumigators can be exposed
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Chronic fluorine intoxication from drinking water
Summary The case of ? 35-year-old woman is described presenting stiffness and severe pain in the spine, gastric disturbances, stomatitis, paresthesias in legs and arms, especially in the u1nar nerve area, loss of mental acuity, visual disturbances and extreme general malaise. On1y ? few clear-cut objective findings were noted, namely: decreased muscular
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Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1?/Sirt3.
Highlights Honokiol attenuated fluoride-induced cognitive deficits in mice. Honokiol prevented neuronal/synaptic injury in the hippocampus of fluoride-treated mice. Honokiol inhibited oxidative stress and mitochondrial abnormalities following fluoride challenge. The AMPK-PGC-1?-Sirt3 pathway was involved in the honokiol’s positive effects on fluoride-induced mitochondrial dysfunction. Oxidative stress and mitochondrial dysfunction contribute greatly to
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Exposure to fluoridated public water supplies and child health and behaviour.
The relationship between duration of exposure to fluoridated public water supplies and measures of child health and behaviour was studied for a birth cohort of Christchurch children. This study showed no association between exposure to fluoridated water and a large range of measures of child health and behaviour taken during
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