Excerpts
In an attempt to find the reason why the anaerobic breakdown of glucose in brain is less in poliomyelitis, experiments were performed using sodium fluoride as an inhibitor (Table II). The percentage inhibition resulting from fluoride was consistently higher in the normal than in the infected brain, particularly with lower concentrations of fluoride. The residual glycolysis in poliomyelitic brain treated with fluoride was equal to the glycolysis in normal brain with fluoride in every experiment. One of the major effects of fluoride is to inhibit glycolysis at the stage of breakdown of phosphoglycerate to phosphopyruvate. In contrast to the results with fluoride, preliminary experiments indicate that monoiodoacetate exerts an equal inhibitory effect on anaerobic glycolysis of normal and poliomyelitic brain suspensions…
TABLE II
The Effect of Sodium Fluoride on Anaerobic Glycolysis…
SUMMARY
1. During paralysis, the brain of the mouse infected with poliomyelitis virus shows on test after mincing a decrease in anaerobic glycolysis with no significant change in oxygen utilization. The decrease in anaerobic glycolysis varies from 5 per cent to 50 per cent.
2. Sodium fluoride produces a greater inhibition of anaerobic glycolysis in normal than in poliomyelitic brain…
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[Studies on fluoride concentration and cholinesterase activity in rat hippocampus].
OBJECTIVE: To study the accumulation of fluoride in rat hippocampus and its effect on cholinesterase activity. METHODS: Rats were subchronically exposed to NaF, and fluoride concentration and cholinesterase activity in rat hippocampus were determined. RESULTS: Fluoride concentration in rat hippocampus was significantly correlated with the dosage of fluoride, and there
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Mitigation by black tea extract of sodium fluoride induced histopathological changes in brain of mice
Sixty young adult inbred Swiss strain male albino mice (Mus musculus) were randomly divided into six equal groups. Groups I and II served as control and antidote groups, respectively. Groups III and IV were orally administered 0.2 and 0.4 mg sodium fluoride (NaF) in 0.2 mL of deionized water/animal/day (= 6 mg and
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Fluoride occurrences, health problems, detection, and remediation methods for drinking water: A comprehensive review.
Highlights In this review, occurrence of fluoride ion has been highlighted with its worldwide and national scenario. The effect of fluoride ions in the environment, as well as the human body, was elaborated. Fluoride detection technologies with special reference to Sensor based technologies Removal techniques were discussed including process
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Evaluation of free radical-scavenging and anti-oxidant properties of black berry against fluoride toxicity in rats
Oxidative damage to cellular components such as lipids and cell membranes by free radicals and other reactive oxygen species is believed to be associated with the development of degenerative diseases. Fluoride intoxication is associated with oxidative stress and altered anti-oxidant defense mechanism. So the present study was extended to investigate
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Extract of Ginkgo biloba leaves attenuates neurotoxic damages in rats and SH-SY5Y cells exposed to a high level of fluoride.
Background Potential protection against the neurotoxic damages of high levels of fluoride on rats and SH-SY5Y cells by extract of Ginkgo biloba leaves, as well as underlying mechanisms, were examined. Methods The rats were divided randomly into 4 groups, i.e., control, treatment with the extract (100 mg/kg body weight, gavage once daily), treatment with
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are 78 studies reporting reduced IQ (75 studies with children and 3 studies with adults) and several on the impaired learning/memory in animals. And there are studies which link
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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