SUMMARY: Brain tissues for neurohistopathological study were obtained at
autopsy from albino rabbits that had been subcutaneously injected for 15
weeks with 0, 5, 10, 20, and 50 mg of sodium fluoride in 1 mL of aqueous solu-
tions/kg bw/day. Neuropathological changes occurred with loss of the mo-
lecular layer and glial cell layer in the brain tissues of rabbits exposed to the
three higher fluoride doses. The Purkinje neurones exhibited chromatolysis
and acquired a “ballooned” appearance. Nissl substance showed various de-
grees of decrease and even complete loss. Fragmented particles were re-
tained in the perinuclear zone. The perikaryon showed vacuolization, and
spheroid bodies were present in the neuroplasm. These cytoplasmic inclu-
sions appeared as various sized ovoid bodies or elongated eosinophilic
masses due to which the nucleus was shifted to the periphery. These neuro-
toxic changes in the brain suggested that there was a direct action of fluoride
upon the nerve tissue which was responsible for central nervous system
problems such as tremors, seizures, and paralysis indicating brain dysfunc-
tion seen at the two highest doses.
A correlation between serum vitamin, acetylcholinesterase activity and IQ in children with excessive endemic fluoride exposure in Rajasthan, India
Fluoride is widely distributed in nature and a direct source of adverse health effects in human populations. Fluoride poisoning attributed by long-term exposure to high levels of fluoride [is] called fluorosis. The present study was carried out among 9-14 years old school children of Dausa district, Rajasthan India. The subjects
Changes in fluoride levels in the liver, kidney, and brain and in neurotransmitters of mice after subacute administration of fluoride
The effects of fluoride after subacute oral administration of NaF at levels of 0, 1, 5, 25, and 125 ppm F– were evaluated in adult male BALB/c mice. Fluoride levels in the murine liver, kidney, and cerebrum after one month were determined using a highly sensitive flow-injection apparatus with a
Psychopharmacology of fluoride: a review
Although the blood-brain barrier is relatively impermeable to fluoride, it does not pose an absolute barrier and fluoride has the ability to enter the brain. The literature was examined to assess the quality of the evidence for cerebral impairment occurring due to exposure to fluoride from therapeutic or environmental sources.
Determination of the contents of amino-acid and monoamine neurotransmitters in fetal brains from a fluorosis-endemic area.
The contents of five types of amino-acid neurotransmitters and three types of monoamine neurotransmitters in the brains of fetuses aborted through induced labor in a chronic fluorosis-endemic area were determined. Findings revealed that the content of the excitatory amino acid, aspartic acid, was significantly lower than in the fetuses from
Effects of fluoride on neurotransmitters in brain regions of rats exposed to fluoride in drinking water for two months
Fluoride has long been known as an environmental pollutant. Toxic neurological effects of fluoride have been reported in experimental animals by oral exposure to fluoride, but effects on neural transmitters are not clear. Adult male rats were administered fluoride via their drinking water at concentrations of 0, 50, 100, and 200 ppm (as fluoride
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
Fluoride & IQ: 67 Studies
As of May 2020, a total of 75 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 67 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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