SUMMARY: Brain tissues for neurohistopathological study were obtained at
autopsy from albino rabbits that had been subcutaneously injected for 15
weeks with 0, 5, 10, 20, and 50 mg of sodium fluoride in 1 mL of aqueous solu-
tions/kg bw/day. Neuropathological changes occurred with loss of the mo-
lecular layer and glial cell layer in the brain tissues of rabbits exposed to the
three higher fluoride doses. The Purkinje neurones exhibited chromatolysis
and acquired a “ballooned” appearance. Nissl substance showed various de-
grees of decrease and even complete loss. Fragmented particles were re-
tained in the perinuclear zone. The perikaryon showed vacuolization, and
spheroid bodies were present in the neuroplasm. These cytoplasmic inclu-
sions appeared as various sized ovoid bodies or elongated eosinophilic
masses due to which the nucleus was shifted to the periphery. These neuro-
toxic changes in the brain suggested that there was a direct action of fluoride
upon the nerve tissue which was responsible for central nervous system
problems such as tremors, seizures, and paralysis indicating brain dysfunc-
tion seen at the two highest doses.
Proteome alterations in cortex of mice exposed to fluoride and lead
Both fluoride and lead can cross the blood-brain barrier and produce toxic effects on the central neural system, resulting in low learning and memory abilities, especially in children. In order to identify the proteomic pattern in the cortex of young animals, from the beginning of fertilization to the age of
Alterations in plasma and tissue acetylcholinesterase activity following repeated oral exposure of chlorpyrifos alone and in conjunction with fluoride in Wistar Rats
Concurrent exposures of more than one environmental contaminants are commonly encountered by human beings and animals. This study investigated the effect of chlorpyrifos alone and in conjunction with fluoride on plasma and tissue acetylcholinesterase (AChE) activity in wistar rats. Fluoride at 1 or 10 ppm in drinking water produced significant (P < 0.05)
Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.
Highlights NaF exposure caused developmental neurotoxicity. NaF-induced neuronal apoptosis results from autophagic flux blockage. Raised lysosomal pH disrupting lysosomal degradation caused autophagic flux blockage. V-ATPase is a crucial factor regulating neuronal lysosomal pH. Upregulation of V-ATPase alleviate NaF-induced developmental neurotoxicity. Fluoride is capable of inducing developmental neurotoxicity, yet its mechanisms
Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats
Nine-six Wistar rats were randomly divided into four groups of 24 rats in each group (female:male = 1:1). Over a period up to 90 days, with one untreated group as controls, the other three groups were administered, respectively, high fluoride (100 mg NaF/L), high arsenic (50 mg As2O3/L), or both
Aluminum and fluoride impacts cortex and hippocampus structure in rats: protective role of resveratrol.
Metals such as aluminum and Fluoride have been implicated in the etiology of several neurodegenerative disorders . Resveratrol, a natural polyphenol, exerting a wide range of biological and pharmacological activities including its antioxidative properties against neurodegenerative disorders through its ability to lessen oxidative stress. Rats were divided in to 4
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
Fluoride & IQ: 76 Studies
• As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure
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