SUMMARY: Brain tissues for neurohistopathological study were obtained at
autopsy from albino rabbits that had been subcutaneously injected for 15
weeks with 0, 5, 10, 20, and 50 mg of sodium fluoride in 1 mL of aqueous solu-
tions/kg bw/day. Neuropathological changes occurred with loss of the mo-
lecular layer and glial cell layer in the brain tissues of rabbits exposed to the
three higher fluoride doses. The Purkinje neurones exhibited chromatolysis
and acquired a “ballooned” appearance. Nissl substance showed various de-
grees of decrease and even complete loss. Fragmented particles were re-
tained in the perinuclear zone. The perikaryon showed vacuolization, and
spheroid bodies were present in the neuroplasm. These cytoplasmic inclu-
sions appeared as various sized ovoid bodies or elongated eosinophilic
masses due to which the nucleus was shifted to the periphery. These neuro-
toxic changes in the brain suggested that there was a direct action of fluoride
upon the nerve tissue which was responsible for central nervous system
problems such as tremors, seizures, and paralysis indicating brain dysfunc-
tion seen at the two highest doses.
Correlations between fluoride concentration and free radical parameters in soft tissues of rats.
In previous studies we investigated the impact of subchronic exposure of rats to sodium fluoride administered in their drinking water as it affected selected biochemical parameters in their soft tissues and organs. The activity of glutathione peroxidase and the concentrations of fluoride, reduced glutathione (GSH), substances reacting with thiobarbituric acid (TBARS), and carbonyl groups were determined in kidney,
Co-exposure to fluoride and sulfur dioxide on histological alteration and DNA damage in rat brain.
Fluoride (F) and sulfur dioxide (SO2 ) are the two common environmental contaminants that are associated with neurotoxicity. The present study was conducted to explore individual and combined exposure effects of F and SO2 on histological alteration and DNA damage in rat brain. For this, male Wistar albino rats were
GSTO1 acts as a mediator in sodium fluoride-induced alterations of learning and memory related factors expressions in the hippocampus cell line.
The mechanism of GSTO1, as a high-risk factor for neurological damage, in sodium fluoride (NaF)-induced learning and memory impairment remained still unclear. Hence, in this study, we used the siRNA-GSTO1 HT22 model to explore the effect of NaF and siRNA-GSTO1 on the viability, and proliferation rate of HT22cells, as well
Effects of chronic fluorosis on CAMKIIA, C-FOS, BAX, and BCL-2 channel signalling in the hippocampus of rats
In this study, the neurotoxicity of fluoride (F) in the hippocampus of rats exposed to 15, 30, and 60 mg NaF/L in their drinking water for nine months was investigated. Compared with the control (<0.5 mg F/L), significant increases in the expression of calcium/calmodulin-dependent kinase II alpha (CaMKII?) (F=5.228, p<0.05)
Fluoride-induced brain damages in suckling mice
In order to reveal mechanisms of brain damages resulted from fluoride toxicity, we treated adult female mice of Swiss Albinos strain by 500 ppm NaF (226 ppm F?) in their drinking water from the 15th day of pregnancy until the day 14 after delivery. All mice were sacrificed on day 14 after
Related Studies :
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
Fluoride & IQ: 67 Studies
As of May 2020, a total of 75 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 67 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
Related FAN Content :