Abstract

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    Previous behavioural studies shows that excessive exposure of fluoride caused diminished intelligent quotient in children compared to the normal children (Wang et al., 2004) and sodium fluoride intoxicated rat exerted loss of memory and learning disability (Yaning et al., 2005). In the present study postnatal rats aged day 21 and

  • Evaluation of Metformin and Dehydrozingerone against fluorosis induced neurodevelopmental toxicity in preclinical models.

    Background: Inorganic fluoride is widely used in dental practices to treat problems like dental caries and also to prevent bone related issues. It has been reported that exposure to excess amounts of fluoride either through drinking water or other sources impairs vital functions of the body and can

  • Melatonin ameliorates fluoride induced neurotoxicity in young rats: an in vivo evidence

    Objective: Developing brain is highly vulnerable to environmental toxins. Recently, fluoride was declared as a developmental neurotoxin and heralded search for natural neuroprotectant. In the present study, we have evaluated the neuroprotective and anti-inflammatory efficacy of melatonin in fluoride induced neurotoxicity. Methods: Animals were divided into following groups; the first group

  • Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the a7 nicotinic receptor and oxidative stress.

    Daily exposure to fluoride (F) depends mainly on the intake of this element with drinking water. When administered during gestation and lactation, F has been associated with cognitive deficits in the offspring. However, the mechanisms underlying the neurotoxicity of F remain obscure. In the current study, we investigated the effects

  • Sirt3-mediated mitochondrial dysfunction is involved in fluoride-induced cognitive deficits.

    Highlights Fluoride induces cognitive deficits in mice. Fluoride exposure results in neural/synaptic injury in the hippocampus of mice. Mitochondrial dysfunction contributes to neural/synaptic alternations. Inhibition of Sirt3 is involved in the fluoride-evoked mitochondrial abnormalities. Abstract Excessive fluoride is capable of inducing cognitive deficits, but the mechanisms remain elusive. This study aimed

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  • Fluoride content in tea and its relationship with tea quality.

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