Fluoride (F) is a toxic and reactive element, and exposure to it passes almost unnoticed, with the consumption of tea, fish, meat, fruits, etcetera and articles of common use such as: toothpaste additives; dental gels, non-stick pans and razor blades as Teflon. It has also been used with the intention of reducing the dental cares.
Fluoride can accumulate in the body, and it has been shown that continuous exposure to it causes damaging effects on body tissues, particularly the nervous system directly without any previous physical malformations.
Several clinical and experimental studies have reported that the F induces changes in cerebral morphology and biochemistry that affect the neurological development of individuals as well as cognitive processes, such as learning and memory. F can be toxic by ingesting one part per million (ppm), and the effects they are not immediate, as they can take 20 years or more to become evident.
The prolonged ingestion of F may cause significant damage to health and particularly to the nervous system. Therefore, it is important to be aware of this serious problem and avoid the use of toothpaste and items that contain F, particularly in children as they are more susceptible to the toxic effects of F.
Neurobehavioral toxicity produced by sodium fluoride in drinking water of laboratory rats
The effect of exposure to different concentrations of sodium fluoride (Na-F) for different durations on learning and memory tasks in rats (non-associative and associative learning) was assessed in our study. Three groups of fifteen pregnant Wistar female rats each, were administered Na-F in drinking water at one of three concentrations;
[Effect of chronic fluorine poisoning on the expression of nNOS protein in Hippocampus of rats].
Objective To investigate the mechanism of chronic fluorine poisoning on hippocampus of rats. Methods The changes of positive nNOS expression in control group given drinking tap water,100 mg/L(low fluorine group),200 mg/L(high fluorine group),were observed by ABC immunohistochemisty. Results The expression of nNOS in the region of CA1, CA3 and dentate gyrus (DG)
Fluoride Alteration of [3H]Glucose Uptake in Wistar Rat Brain and Peripheral Tissues.
The present study was designed to investigate the role of postnatal fluoride intake on [3H]glucose uptake and transport in rat brain and peripheral tissues. Sodium fluoride (NaF) in a concentration of 10 or 50 ppm was added to the drinking water of adult Wistar rats. The control group received distilled
Symposium on the non-skeletal phase of chronic fluorosis: The spinal cord
The author presents evidence of damage to the spinal cord in skeletal fluorosis. Since pressure on the cord by osteophytes was ruled out, direct action of fluoride on cord tissue is likely to be responsible for this condition.
Protective effects of aqueous extract of fruit pulp of Tamarindus indica on motor activity and metabolism of the gastrocnemius muscle of rats treated with fluoride
This study reports the protective effects of tamarind ingestion against fluoride induced changes on motor activity and metabolism of Gastrocnemius muscle (GM) of rats. The male Wistar rats were divided into four groups - control, fluoride treated i.p. (20 mg NaF/Kg bw) and Tamarind (Tamarindus indicus III -150mg/kg bw and
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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