Fluoride (F) is a toxic and reactive element, and exposure to it passes almost unnoticed, with the consumption of tea, fish, meat, fruits, etcetera and articles of common use such as: toothpaste additives; dental gels, non-stick pans and razor blades as Teflon. It has also been used with the intention of reducing the dental cares.
Fluoride can accumulate in the body, and it has been shown that continuous exposure to it causes damaging effects on body tissues, particularly the nervous system directly without any previous physical malformations.
Several clinical and experimental studies have reported that the F induces changes in cerebral morphology and biochemistry that affect the neurological development of individuals as well as cognitive processes, such as learning and memory. F can be toxic by ingesting one part per million (ppm), and the effects they are not immediate, as they can take 20 years or more to become evident.
The prolonged ingestion of F may cause significant damage to health and particularly to the nervous system. Therefore, it is important to be aware of this serious problem and avoid the use of toothpaste and items that contain F, particularly in children as they are more susceptible to the toxic effects of F.
Tamarind seed coat extract restores fluoride-induced hematological and biochemical alterations in rats.
Fluoride (F-) is becoming an ineluctable environmental pollutant causing deleterious effects in humans. In the present study, we examined whether tamarind seed coat extract (TSCE) is beneficial against the F--induced systemic toxicity and hematological changes. Wistar rats were randomly grouped as follows: group I served as control; group II intoxicated
Studies on the DNA and RNA contents of heart, liver and kidney of rats with chronic fluorosis
17 rats with chronic fluorosis induced by prolonged drinking of water containing 50 ppm fluorine and 17 rats drinking low-fluorine water served as control were used to study the DNA and RNA contents of heart, liver and kidney. The findings suggest that excessive accumulation of fluorine can suppress the synthesis
OP V – 2 Prenatal fluoride exposure and neurobehavior among children 1–3 years of age in Mexico
Background/aim Recent studies report an inverse association between fluoride (F) exposure and IQ in children, but few included individual measures of exposure or assessed associations with prenatal exposure using a prospective study design. Methods This study utilised the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) birth cohort and archived pregnancy samples
Long-term exposure to fluoride as a factor promoting changes in the expression and activity of cyclooxygenases (COX1 and COX2) in various rat brain structures.
Highlights long-term exposure to fluoride during the development leads to the decrease in the expression of COX1 and COX2 in the brain. a statistically significant increase in PGE2 concentration and COX2 immunexpression was observed in hippocampus. exposure to fluoride in the prenatal and neonatal period may result in the development
The Evolving Science of Fluoride Exposure and Neurocognitive Effects: Does Timing of Exposure and Sex Matter? [Review 2]
Background: Fluoride is associated with IQ deficits during early brain development, but the period in which children are most vulnerable has not been established. We assessed sex-specific effects of fluoride on IQ across prenatal, infancy, and early childhood windows. Methods: Repeated exposures from 596 mother-child pairs in the Maternal-Infant Research on
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
Fluoride's Direct Effects on Brain: Animal Studies
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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