Abstract
Objective To investigate the mechanism of chronic fluorine poisoning on hippocampus of rats.
Methods The changes of positive nNOS expression in control group given drinking tap water,100 mg/L(low fluorine group),200 mg/L(high fluorine group),were observed by ABC immunohistochemisty.
Results The expression of nNOS in the region of CA1, CA3 and dentate gyrus (DG) in hippocampus of low fluorine group and high fluorine group was significantly reduced, with the increase of fluorine, the expression of nNOS in the region of CA1 was reduced significantly, region CA3 and DG also reduced.
Conclusion Chronic fluorine poisoning can restrain the expression of nNOS in Hippocampus of rats.
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National Toxicology Program Systematic literature review of animal studies.
Official citation: NTP (National Toxicology Program). 2016. Systematic Literature Review on the Effects of Fluoride on Learning and Memory in Animal Studies. NTP Research Report 1. Research Triangle Park, NC: National Toxicology Program. Conclusion (page 59): Very few studies assessed learning and memory effects in experimental animals (rats and mice) at exposure
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Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity.
Highlights Excessive ER stress plays an important role in NaF-induced neurotoxicity. NaF-induced neuronal death is caused by ER stress-elicited apoptosis and the impaired autophagic flux. Impaired autophagic flux was mediated by excessive ER stress in NaF-induced neurotoxicity. Fluoride is capable of inducing neurotoxicity, but its mechanisms remain elusive. This study
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GSTO1 acts as a mediator in sodium fluoride-induced alterations of learning and memory related factors expressions in the hippocampus cell line.
The mechanism of GSTO1, as a high-risk factor for neurological damage, in sodium fluoride (NaF)-induced learning and memory impairment remained still unclear. Hence, in this study, we used the siRNA-GSTO1 HT22 model to explore the effect of NaF and siRNA-GSTO1 on the viability, and proliferation rate of HT22cells, as well
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Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the a7 nicotinic receptor and oxidative stress.
Daily exposure to fluoride (F) depends mainly on the intake of this element with drinking water. When administered during gestation and lactation, F has been associated with cognitive deficits in the offspring. However, the mechanisms underlying the neurotoxicity of F remain obscure. In the current study, we investigated the effects
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Fluoride activates microglia, secretes inflammatory factors and influences synaptic neuron plasticity in the hippocampus of rats.
Epidemiological studies have reported that highly fluoridated drinking water may significantly decrease the Intelligence Quotient (IQ) of exposed children. It is thought that synaptic plasticity is the basis of learning and memory skills in developing children. However, the effect on synaptic plasticity by activated microglia induced via fluoride treatment is
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Fluoride's Direct Effects on Brain: Animal Studies
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Fluoride & IQ: 76 Studies
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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