Abstract

Objective  To investigate the mechanism of chronic fluorine poisoning on hippocampus of rats.

Methods  The changes of positive nNOS expression in control group given drinking tap water,100 mg/L(low fluorine group),200 mg/L(high fluorine group),were observed by ABC immunohistochemisty.

Results  The expression of nNOS in the region of CA1, CA3 and dentate gyrus (DG) in hippocampus of low fluorine group and high fluorine group was significantly reduced, with the increase of fluorine, the expression of nNOS in the region of CA1 was reduced significantly, region CA3 and DG also reduced.

Conclusion  Chronic fluorine poisoning can restrain the expression of nNOS in Hippocampus of rats.

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