Abstract
Objective To study the serotonin neuron in rat with chronic fluorosis.
Methods Animal model of chronic fluorosis in male rats was established with administration of large doses fluoride in drinking water. The qualitative and quantitative analysis of serotonin (5-HT) neurons in nucleus raphe magnus with immunocytochemical technique was done.
Results The results showed that the number of 5-HT positive neurons in nucleus raphe magnus decreased in fluorosis group with the declared 5-HT positive particles in cytoplasm. With cell image analysis, the 5-HT contents in the 5-HT neurons decreased significantly in fluorosis group.
Conclusion These results suggest that the administration of larger doses of fluoride will directly damage the central nervous system.
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Effect of fluoride on express of cytokines in the hippocampus of adult rats
To investigate the effects of fluoride on the expression levels of cytokines in the rat hippocampus, 60 adult Wistar albino rats were randomly divided into four groups of 15 rats each, whose drinking water contained: (1) double distilled water (the control group); (2) 25 mg sodium fluoride (NaF)/L, (11.3 mg
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Subchronic neurotoxicity in rats of the structural fumigant, sulfuryl fluoride
Inhalation exposure of male and female Fischer 344 rats to sulfuryl fluoride [Vikane (Dow Chemical Company) gas fumigant] at 300 ppm for 6 hr/day, 5 days week, for 13 weeks caused diminished weight gain, dental fluorosis, a slight decrease in grooming, decreased flicker fusion threshold, slowing of flash, auditory and
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Protective effect of resveratrol on fluoride induced alteration in protein and nucleic acid metabolism, DNA damage and biogenic amines in rat brain
Fluoride, a well-established environmental carcinogen, has been found to cause various neurodegenerative diseases in human. Sub-acute exposure to fluoride at a dose of 20mg/kgb.w./day for 30 days caused significant alteration in pro-oxidant/anti-oxidant status of brain tissue as reflected by perturbation of reduced glutathione content, increased lipid peroxidation, protein carbonylation, nitric
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Buffalo (Bubalus bubalis) epiphyseal proteins give protection from arsenic and fluoride-induced adverse changes in acetylcholinesterase activity in rats
The objective of this study was to determine the effect of fluoride (F) and arsenic (As) on the activity of acetylcholinesterase (AChE), a critically important nervous system enzyme, and to test the protective role of buffalo epiphyseal (pineal) proteins (BEP) in rats. Arsenic (20 mg/kg BW, intraperitoneally) and F (150
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Symposium on the non-skeletal phase of chronic fluorosis: The spinal cord
The author presents evidence of damage to the spinal cord in skeletal fluorosis. Since pressure on the cord by osteophytes was ruled out, direct action of fluoride on cord tissue is likely to be responsible for this condition. Neurological complications of skeletal fluorosis have been described in endemic areas, especially in
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are 78 studies reporting reduced IQ (75 studies with children and 3 studies with adults) and several on the impaired learning/memory in animals. And there are studies which link
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Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
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